西安交通大学学报（医学版）2012，Vol.33Issue(5)：617-621,625,6.
宁夏回族高血压患者MSA2756G、CYP2C9*3多态性的研究
CYP2C9 * 3 and MSA2756G gene polymorphisms in hypertensive patients of Ningxia Hui nationalities
摘要
Abstract
Objective To investigate the distribution of CYP2C9*3 and MSA2756G related to disease gene and drugs therapy in hypertensive patients of Ningxia Hui nationalities. Methods We analyzed genotypes by amplification-created restriction sites (ACRS) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in hypertensive patients so as to explore the relation of the genotypes with hypertension in the Ningxia Hui population by x2 and I test- Results ① The frequency of allele G was 10.25% in control group and 14.04% in hypertension group, without significant difference between the two groups (P>0.05). In the males, the frequency of allele G was 11. 50% in control group and 8. 79% in hypertension group, without significant difference between the two groups(P>0.05). In the females, the frequency of allele G was 9.00% in control group and 19. 54% in hypertension group, with a significant difference between the two groups ( P < 0. 05). In hypertension group, the frequency of allele G was 8.79% in the male patients and 19.54% in the female patients. with a significant difference between the males and females (P<0.05). ② The frequency of allele C was 3.00% in control group and 3.37% in hypertension group, with no significant difference between the two groups (P>0.05). In the males, the frequency of allele C was 3. 50% in control group and 4.40% in hypertension group, with no significant difference between the two groups (P>0.05). In the females, the frequency of allele C was 2.50% in control group and 2. 30% in hypertension group, without significant difference between the two groups (P>0.05). Conclusion The allele G of MSA2756G is a risk factor for hypertension in female hypertensive patients of Ningxia Hui nationalities, but it is not related to the men.关键词
高血压/CYP2C9/甲硫氨酸合成酶/多态性/宁夏回族Key words
hypertension/CYP2C9/methionine synthases polymorphism/Ningxia Hui nationalities分类
医药卫生引用本文复制引用
李居怡,邹吉利,王健,刘新国,陈永刚,白丹,王雄,吴金虎..宁夏回族高血压患者MSA2756G、CYP2C9*3多态性的研究[J].西安交通大学学报（医学版）,2012,33(5):617-621,625,6.基金项目
宁夏自然科学基金资助项目(No.NZ07109) （No.NZ07109）
宁夏卫生厅重点科研课题(No.W200707) （No.W200707）
