西安交通大学学报（医学版）2012，Vol.33Issue(5)：640-643,650,5.
特发性膜性肾病与膜增生性肾炎的比较
Comparison between idiopathic membranous nephropathy and membranoproliferative nephritis
张亚莉 1姜莎莎 1冯婕 1严骏飞 1郝大鹏 1冯学亮1
作者信息
- 1. 西安交通大学医学院第一附属医院肾病医院,陕西西安710061
- 折叠
摘要
Abstract
Objective To understand the characteristics of idiopathic membranous nephropathy (IMN) and primary membranoproliferative glomerulonephritis (PMPGS) and their differences based on contrastive analysis of their clinical and pathological information. Methods We made a contrastive analysis of clinical and pathological information of IMN (551 cases) and PMPGS (105 cases) in the past 20 years in our hospital. Results ① Male patients outnumbered female ones in both groups with little difference (P>0.05). ② Significant differences were found between IMN and PMPGS in average age, namely, (47.22±16.32) and (39.10± 15.47), respectively (P< 0.01). ③ Large differences between IMN and PMPGS in median course of disease, namely, 4 and 6 months, respectively; the course of disease ranged 1-11 months in IMN and 3-24 months in PMPGS in 50% cases, respectively (f<0.01). ④Nephritic syndrome was the major clinical manifestation ici both groups with little difference (P> 0.05). ⑤Hematuria occurred in 33.76% (186/551) of IMN patients and 56.19% (59/105) of MPGS ones, with significant difference (P<0.01).⑥ The two groups did not differ significantly in blood pressure, quantitative analysis of urinary album, concentration of album, IgG and lgA (P>0.05), but in concentration of IgM, C3 and C, and the ratio of existing complement reduction (C3) (P<0.01). ⑦ Large differences were found in incidence of renal insufficiency as well as the concentration of BUN and Scr between IMN and PMPGS (P<0.01). ⑧ As to the overall disease risk degree, there were large differences between the two groups (P<0. 01). ⑨ Pathological features: Although immunoglobulin deposition was strong in both diseases, it was significantly stronger in IMN than in PMPGS (P<0.01). Conclusion ① Male patients outnumber female ones in both diseases. ② Nephritic syndrome
is the major clinical manifestation. ③ Hematuria is more common in PMPGS than in IMN) the ratio of existing complement reduction (C3) is higher in PMPGS. ④ Renal functional lesion is not so serious in IMN as in PMPGS.
关键词
膜性肾病/膜增生性肾小球肾炎/危险度/临床表现/肾功能不全Key words
membranous nephropathy/membranoproliferative glomerulonephritis/risk degree/clinical mani-festation分类
医药卫生引用本文复制引用
张亚莉,姜莎莎,冯婕,严骏飞,郝大鹏,冯学亮..特发性膜性肾病与膜增生性肾炎的比较[J].西安交通大学学报（医学版）,2012,33(5):640-643,650,5.
