现代妇产科进展2012，Vol.21Issue(8)：600-603,4.
高危型HPV DNA检测在宫颈上皮内瘤变及宫颈早期鳞癌锥切术后随访中的应用及意义
Application and significance of high risk HPV(HR-HPV) DNA testing in the follow-ups after cold knife conization in cervical intraepithelial neoplasia (CIN) and micro invasive cervical squamous cell cancer
李岩 1崔竹梅 1娄艳辉 1刘丽芝 1唐蕊 1韩汶君1
作者信息
- 1. 青岛大学医学院附属医院妇科,青岛266003
- 折叠
摘要
Abstract
Objective: To evaluate the application and significance of high risk HPV (HR-HPV) DNA detection in the follow-ups after cold knife conization (CKC)in cervical intra-epithelial neoplasia(CIN)and cervical squamous cell cancer of Stage IA1. Methods; A retrospective review was performed on 308 women who underwent of CINII ~ Ⅲ and cervical squamous cell cancer of Stage IA1 were treated by cold knife conization between Jan. 2008 to Oct. 2010 in our hospital. Then the patients were followed up by HR-HPV DNA testing(hybrid capture 2,HC2) and thin-layer liquid-based cytology (LCT) to observe the clearance of HR-HPV and recurrence of cervical lesions. The related factors of persistent infection of HR-HPV and persistent lesions or recurrence after CKC were analyzed. Results: By the end of follow-up, 10 patients were evidenced persistent lesions or recurrence. The persistent lesions or recurrence were more likely to occur when the HR-HPV infection persisted (P<0. 001). The pre-conization HR-HPV DNA high viral load and three- or four-quadrant disease involved were risk factors for predicting HR-HPV persistent infection after conization. HR-HPV DNA high viral load ( RIUs/COSs 500) was the only significantly independent risk factor for the persistent lesions or recurrence after conization. Conclusion: HR-HPV persistent infection after conization is a significantly important factor of the persistent lesions or recurrence. The pre-conization HR-HPV DNA high viral load is the only significantly independent risk factor of HR-HPV persistent infection and the persistent lesions or recurrence. Patients with high viral load prior to conization should be closely followed.关键词
宫颈肿瘤/宫颈上皮内瘤样病变/人乳头瘤病毒/高危型HPV DNA检测/宫颈锥切术/持续感染/病灶持续/复发Key words
Cervical neoplasms/Cervical intraepithelial neoplasia/Human papillomavirus/High risk HPV DNA testing/Cervical conization/Persistent infection/Persistent lesions/Recurrence分类
医药卫生引用本文复制引用
李岩,崔竹梅,娄艳辉,刘丽芝,唐蕊,韩汶君..高危型HPV DNA检测在宫颈上皮内瘤变及宫颈早期鳞癌锥切术后随访中的应用及意义[J].现代妇产科进展,2012,21(8):600-603,4.
