医药导报2012，Vol.31Issue(9)：1109-1112,4.DOI:10.3870/yydb.2012.09.001
仙人掌多糖对大鼠局灶性脑缺血的神经保护作用
Neuroprotective Effect of Cactus Polysaccharides on Focal Cerebral Ischemia in Rats
摘要
Abstract
Objective To study the neuroprotective effect of cactus polysaccharides (CP) on ischemia/reperfusion(I/ R) injury induced by the middle cerebral artery occlusion ( MCAO) in rats. Methods The male SD rats were randomly divided into sham-operated, MCAO/R model group, NS-treated group,CP- treated group (200 mg · kg-1 · d-1 ,ip).The MCAO/ R model was made by MCAO method. The neurological deficits were detected at 3 h,6 h and 8 h after MCAO for 2 h and reperfusion; The cerebral infarct volume was detected by TTC staining 8 h later, the brain tissue sections of MCAO for 2 h and reperfusion for 22 h were stained by hematoxylin-eosin (H&E) for the morphological observation under microscope. Results Compared to the NS-treated group,the neurological deficit scores of CP-treated group after reperfusion for 8 h was decreased by (2.35±0.47)(P<0.05),in,company with the. Loss of infarct volume(P<0. 05 ). The rat cortical and hippocampal neuronal cell loss,gliosis,nuclear condensation and nuclear deep dyeing were significantly alleviated (P<0.05) .Conclusion The CP can attenuate of arterial embolism in rats and ameliorate cerebral ischemia, which possessing a neuroprolective effect.关键词
仙人掌多糖/大脑中动脉栓塞/缺血-再灌注/神经保护Key words
Cactus polysaccharides (CP) / Middle cerebral artery occlusion ( MCAO) / Ischemia/reperfusion(I/R) injury/ Neuroprotection分类
医药卫生引用本文复制引用
唐焜,谢小慧,陈志达,陈扬,郭莲军..仙人掌多糖对大鼠局灶性脑缺血的神经保护作用[J].医药导报,2012,31(9):1109-1112,4.基金项目
中央高校基本科研业务费专项资金资助项目(2011TS073) （2011TS073）
华中科技大学研究生科技创新基金资助项目 （）
华中科技大学2011年第二批大学生科技创新基金资助项目 （）
华中科技大学2012年第一批大学生创业创新基金资助项目(104872012169) （104872012169）
