医药导报2012，Vol.31Issue(9)：1125-1127,3.DOI:10.3870/yydb.2012.09.005
草乌配伍贝母对心肌细胞的毒性作用
Toxicity of the Compatibility of Radix Aconiti Kusnezoff and Bulbus Fritillariae Thunbergii on Myocardial Cells
摘要
Abstract
Objective To study the toxic effects of the compatibility of aconitum and fritillaria on myocardial cells. Methods The in vitro toxicity on myocardial cells of suckling mice with the decoction of Radix Aconiti Kusnezoff or Bulbus Fritillaria thunbergii, and both combined were tested, and the effects of which on lactate dehydrogenase ( LDH ) , Ca2+ and suceinodehydrogenase (SDH) were analyzed as well. Results The content of LDH and Ca2+ in the cell transmitter was remarkably elevated at different degrees by the decoction of aconitum or fritillaria and their co-decoction, while the activity of SDH was significantly decreased. The toxicity of co-decoction was more significant than that of each decoction single. Conclusion The toxicity is obviously modified with the compatibility of aconitum and fritillaria, which confirming the scientific concept that " aconitum is against with fritillaria".关键词
草乌/贝母/配伍禁忌/心肌细胞/毒性作用Key words
Radix aconiti kusnezoffiii/ Bulbus fritiUaria thunbergii/ Incompatibility/ Myocardial cells/ Toxirity分类
医药卫生引用本文复制引用
马卫成,徐爱仁,戴晓燕,应景艳,徐锦龙,胡静娜..草乌配伍贝母对心肌细胞的毒性作用[J].医药导报,2012,31(9):1125-1127,3.基金项目
宁波市鄞州区科技计划项目(2009年第三批,编号:25) （2009年第三批,编号:25）
