医药导报2012，Vol.31Issue(9)：1154-1156,3.DOI:10.3870/yydb.2012.09.015
卡巴胆碱对严重脓毒症患者细胞免疫功能的影响
Effects of Carbachol on Cellular Immune Function in Patients with Severe Sepsis
程爱斌 1尚秀娟 1刁增利 1王瑞刚1
作者信息
- 1. 河北联合大学附属医院重症医学科,唐山 063000
- 折叠
摘要
Abstract
Objective To study the clinical effects of carbachol on human leukocyte antigen DR ( HLA-DR) in CD+14 rnonocytes from patients with severe sepsis. Methods A total of 100 cases of patients with severe sepsis were divided into two groups including the treatment, group with 60 and control group with 40. The treatment group was intramuscularly administrated with carbachol al the liose of 0. 2 mg· kg-1 for 7 days on the basis of conventional therapy. While the control group was given with placebo at the same time based on routine treatment. Then the proportion of HLA-DR in CD-12 monocyles and CD+4 ,CD+8 T tell subsets were investigated before and after treatment. Results The levels of HLA-DR in CD+14 monocytes and CD+4 ,CD+8 T cells were significantly increased by earbachol, which were (36. 30±13. 14)% , (40. 81 ± 12. 09)% , (31. 14±3. 63)% .respectively. Conclusion Carbachol can regulate inflammatory reaction status of the body and benefit for the immune function of patients with severe sepsis.关键词
卡巴胆碱/脓毒症/细胞免疫功能Key words
Carbachol/Sepsis/ Cellular immune function分类
医药卫生引用本文复制引用
程爱斌,尚秀娟,刁增利,王瑞刚..卡巴胆碱对严重脓毒症患者细胞免疫功能的影响[J].医药导报,2012,31(9):1154-1156,3.
