中国临床心理学杂志2012，Vol.20Issue(4)：520-522,3.
奎硫平合并丙戊酸镁治疗老年精神分裂症急性期的对照研究
A Comparative Study of Quetiapine with Sustained-release Tablets of Magnesium Valproate in Treatment of Old Patients with Acute Phase of Schizophrenia
摘要
Abstract
Objective: To compare the efficacy and safety of quetiapine with sustained-release tablets of magnesium valproate and quetiapine only in treatment of old patients with acute phase of schizophrenia. Methods: A total of 58 old patients with acute phase of schizophrenia were randomly divided into two groups: study group (quetiapine with magnesion valproate group) and control group (quetiapine only), for treatment of two weeks. Positive and Negative Syndrome Scale (PANSS) and Modified Overt Aggression Scales(MOAS) were used to assess the effects before treatment, at the 1st weekend and 2nd weekend. Treatment Emergent Symptom Scale (TESS) was uesd to evaluate side effects. Results: At the second weekend, there had no significant difference on efficacy between the two groups (p>0.05). At the first weekend and the second weekend, the scores of excitement and agitation of PANSS in the study group were significantly lower than the control group (P<0.05); At the second weekend, the total score of PANSS in the study group was significantly lower than the control group (p<0.05). At the first weekend and the second weekend, the scores of MO AS in both groups were significantly lower than those of their baseline; At the second weekend, there had no significant difference between the two groups. There had no significant difference for TESS in both groups. Conclusion: Quetiapine with sustained-release tablets of magnesium valproate should be a fast, effective and safe way to treat old patients with acute phase of schizophrenia.关键词
奎硫平/丙戊酸镁/老年精神分裂症/急性期Key words
Quetiapine/ Magnesium valproate/ Old patients with schizophrenia/ Acute phrase分类
医药卫生引用本文复制引用
顾培,汪敬,曹江,李宝珠..奎硫平合并丙戊酸镁治疗老年精神分裂症急性期的对照研究[J].中国临床心理学杂志,2012,20(4):520-522,3.
