中国临床药理学杂志2012，Vol.28Issue(8)：600-602,3.
PGC-1α与中枢性肥胖小鼠的机体能量代谢和肥胖发生的相关性
Relationship between peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1α)with body energy metabolism and obesity in central obese mice
摘要
Abstract
Objective To investigate the level of peroxisome proliferator - activated receptor gamma coactivator 1 alpha ( PGC -lα) expression in the central obese mice in order to get the relationship between PGC -1 α with energy metabolism and obesity. Methods To create the obese mod-els, the glutamic sodium was injected by subcutaneous. The body mass index, body temperature, food intake were examined. Besides, the level of PGC - 1α expression in brown adipose, white adipose, liver, lung, heart and brain were detected through RT - PCR. Results The expres-sion of PGC - la in brown adipose, white fat, liver, heart, lung and brain were different. Compared with the normal group, the expression of PGC - 1α was basically reduced in the model group. In addition, the PGC - lα expression in white and brown adipose were up regulated in cold stimulation and more significantly increased in brown adipose. Con-clusion It's likely that PGC - la was associated closely with body ener-gy metabolism and obesity.关键词
能量代谢/肥胖/过氧化物酶体增殖物活化受体γ共激活因子-1αKey words
energy metabolism/ obesity/ peroxisome proliferator - activated receptor gamma coactivator 1 alpha分类
医药卫生引用本文复制引用
杨美子,孙倩,刘欣,孙雪华,栾海云,金勇君..PGC-1α与中枢性肥胖小鼠的机体能量代谢和肥胖发生的相关性[J].中国临床药理学杂志,2012,28(8):600-602,3.基金项目
教育部留学回国人员科研启动基金资助项目 （）
山东省中青年科学家科研奖励基金资助项目(BS2010YY002) （BS2010YY002）
