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评价HPLC-MS/MS法测定人血浆中白藜芦醇浓度的不确定度

刘一 赵立波 刘恩溢 冯婉玉

中国临床药理学杂志2012,Vol.28Issue(8):606-608,3.
中国临床药理学杂志2012,Vol.28Issue(8):606-608,3.

评价HPLC-MS/MS法测定人血浆中白藜芦醇浓度的不确定度

Evaluation of measurement uncertainty for the determination of trans-resveratrol in human plasma by HPLC-MS/MS

刘一 1赵立波 1刘恩溢 1冯婉玉2

作者信息

  • 1. 北京大学 人民医院 药剂科,北京 100044
  • 2. 北京大学 医学部,北京 100191
  • 折叠

摘要

Abstract

Objective To evaluate of measurement uncertainty for the determination of trans - resveratrol in human plasma by HPLC - MS/MS. Methods The uncertainty caused by random effects was evaluated with type A and others were by type B. The combined uncertainty was calculated with all the components. Results The expanded uncertainty for low, medium and high level of trans - resveratrol was 0. 12, 0. 16 and 2. 94 ng ?mL-1, respectively (P =95% ). Conclusion The uncertainty of this experiment was mainly caused by the calibration curve.

关键词

白藜芦醇/HPLC-MS/MS/血浆/不确定度

Key words

trans - resveratrol/ HPLC - MS/MS/ plasma/ uncertainty

分类

医药卫生

引用本文复制引用

刘一,赵立波,刘恩溢,冯婉玉..评价HPLC-MS/MS法测定人血浆中白藜芦醇浓度的不确定度[J].中国临床药理学杂志,2012,28(8):606-608,3.

基金项目

北京大学人民医院研究与发展基金资助项目(RDB-2010-28) (RDB-2010-28)

中国临床药理学杂志

OA北大核心CSCDCSTPCD

1001-6821

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