中国免疫学杂志2012，Vol.28Issue(9)：797-801,5.DOI:10.3969/j.issn.1000-484X.2012.09.007
强骨康疏胶囊对去卵巢骨质疏松大鼠骨细微结构及骨代谢的影响
The effect of Qiang Gu Kang Shu on microstructure and metabolisim of bone tissue in ovariectomized osteoporosis rats
摘要
Abstract
Objective: To observe the effect of Qiang Gu Kang Shu capsules (QGKS) on bone mineral density (BMD) ,bone histomorphometry and microstructure , and expression of OPG and RANKL was ovariectomized rats . Methods: After ovariectomizing, the rats were divided into five groups , including normal control group , model blank group , Qiang Gu Kang Shu (QGKS) low-dose group, QGKS high-dose group, estrogern group. Respectively, to feed drugs to each group for one month. Then, to measure BMD of bilateral femora ,and observe microstructure of femoral trabecular bone ,and detect bone histomorphometry parameters in each group . The protein expression of OPG and RANKL was detected by immunohistochemistry . Results:The femoral BMD and the bone trabecula thickness , area, area percentage were decreased ,the spacing of bone trabecula was increased , expression of OPG was reduced dramatically ,and expression of RANKL was increased dramatically in the model blank group . The indicators in estrogen group and QGKS groups (low and high)were significantly improved. Conclusion:QGKS capsules can maintain bone mass and microstructure of trabecular bone ,and inhibit the expression of RANKL and improve the expression of OPG .关键词
骨质疏松/骨组织形态计量学/骨代谢/骨密度Key words
Osteoporosis/ Bone histomorphometry/ Bone metabolism/ Bone mass density分类
医药卫生引用本文复制引用
冯佳,袁林,苏林冲,向阳..强骨康疏胶囊对去卵巢骨质疏松大鼠骨细微结构及骨代谢的影响[J].中国免疫学杂志,2012,28(9):797-801,5.基金项目
本文为湖北省教育厅课题项目(Q20092906)和湖北民族学院校园项目(MY2011B008) （Q20092906）
