中国免疫学杂志2012，Vol.28Issue(9)：840-842,3.DOI:10.3969/j.issn.1000-484X.2012.09.017
TBX2在甲状腺癌组织中的表达及其临床意义
Expression and clinical significance of TBX2 in thyroid carcinoma
摘要
Abstract
Objective: To detect the expression of TBX2 in thyroid carcinoma and investigate clinical significance . Methods: The expression of TBX2 was detected in 9 normal thyroids, 13 thyroid adenomas and 67 thyroid carcinomas (including 28 thyroid papillary carcinomas, 23 thyroid follcular carcinomas 14 medullary thyroid carcinomas and 2 undifferentiated thyroid carcinomas ) by using RT-PCR. Results:TBX2mRNA had a high positive expression in thyroid carcinoma (there was positive in 56 cases, 83. 6% ) which was significantly different with the expression in normal thyroid tissue (there was positive in 3 cases, 33. 3% ) and thyroid adenoma (there was positive in 6 cases, 46. 2% ) (P <0. 05). The positive expression intensity (relative coefficient) of TBX2mRNA in the thyroid papillary carcinoma , thyroid follcular carcinoma and medullary thyroid carcinoma was 1. 776 ±0. 382、2. 627 ±0. 532、2. 937 ± 0.48 , respectively ( P < 0. 05 ). Its expression intensity was related to the differentiation of thyroid carcinoma and type of histology (P <0.05). Conclusion:TBX2 is possible enhancing factor of thyroid carcinogenesis occurrence and development , and is possible another important reference index of clinical diagnosis and prognosis evaluation of thyroid carcinoma .关键词
甲状腺癌/TBX2/RT-PCRKey words
Hyroid carcinoma/ TBX2/ RT-PCR分类
医药卫生引用本文复制引用
宋晓环,王晓林,孙冬梅,王忠超,高航..TBX2在甲状腺癌组织中的表达及其临床意义[J].中国免疫学杂志,2012,28(9):840-842,3.基金项目
本文为吉林省教育厅"十二五"科学技术研究项目(吉教科合字[2011]第361号) （吉教科合字[2011]第361号）
