中国农业科技导报2012，Vol.14Issue(4)：13-23,11.DOI:10.3969/j.issn.1008-0864.2012.04.03
逆转座子LINE-1在基因组中的调控作用
Regulation of LINE-1 Retrotransposon in Genome
摘要
Abstract
In the eukaryotic genomes,many repetitive DNA sequences were identified in the introns of genes and intervals between the genes,even though they are not translated into protein. Recently these sequences were characterized to participate in regulation of gene expression. Among these repetitive sequences,a retrotransposon called LINE-1,which is widely distributed in the genome,is found to play an important role in cell proliferation,differentiation and tumorigenesis through the mechanisms of affecting gene transcription,genome stability,X chromosome inactivation and genomic evolution,etc. It is known that the aberration of spatial and temporal regulation of gene contributes to tumorigenesis. This article mainly elaborated the structure feature of LINE-1 and the adjusting and control function in the genome that affect gene expression and regulate the biological activities. So the studies on LINE-1 apparently facilitate to understand the formation and development of cancer.关键词
基因表达调控/LINE-1 逆转座子/细胞增殖分化/癌症Key words
regulation and control of gene expression/LINE-1 retrotransposon/cell proliferation and differentiation/cancer分类
生物科学引用本文复制引用
朱运峰,李冠琳..逆转座子LINE-1在基因组中的调控作用[J].中国农业科技导报,2012,14(4):13-23,11.基金项目
国家863计划项目(2011AA02A110)资助. （2011AA02A110）
