摘要
Abstract
Objective To investigate early hemoperfusion combined with hemodiafiltration in treatment of severe acute pancreatitis ( SAP ) and its curative effects on blood internal environment. Methods According to hospital admission order, 51 SAP patients were divided into groups treatment ( n =25 ) and control ( n =26 ). Based on routine treatment, control group were given hemodiafiltration, treatment group combined with hemoperfusion within 24 h. Hemodiastase, renal function, bicarbonate ( HCO3- ), C reactive protein ( CRP ), serum tumor necrosis factor ( TNF - α ), interleukin - 6 ( IL - 6 ) and time length of transference cure, blood purification and hospital stay were determined. Results In control group, 1 died of multiple organ failure ( MOF ), 2 complicated by pancreatic pseudocyst, the others clinically cured. All treatment group cured. The indexes of hemodiastase, renal function, HCO3- , CRP, TNF - α, IL - 6 were lower after treatment than before in 2 groups, the difference was significant ( P < 0. 05 ). AMY, CRP, TNF - α, IL - 6 higher in control group than in treatment group ( P < 0. 05 ). Except extinction time of abdominal distension, the extinction time of abdominal pain and Peritoneal irritation sign, time length of blood purification and hospital stay were shorter in treatment group than in control ( P < 0. 05 ). Conciusion Early hemoperfusion combined with hemodiafiltration in treatment of SAP, clearing serum inflammatory factors timely, stabilizing blood internal environment as soon as possible, avoiding systemic inflammatory reaction and MOF, reducing SAP death rate and incidence of complications and improving SAP prognosis, is worth generalizing and applying clinically.关键词
灌流/血液透析/胰腺炎/内环境稳定Key words
Perfusion/ Hemodialysis/ Pancreatitis/ Homeostasis分类
医药卫生
