摘要
Abstract
Objective To observe the dynamic changes of serum procalcitonin (PCT), tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) in patients with acute pancreatitis (AP) and to investigate their significance in judging AP severity and the occurrence of concurrent infection. Methods 56 AP patients admitted to the First Affiliated Hospital of Suzhou University and Kunshan Hospital of TCM from October 2009 to October 2011 were selected. Among the patients, 21 cases were mild acute pancreatitis (MAP, MAP group) and 35 cases were severe acute pancreatitis (SAP, SAP group) . 5 patients in SAP group combined with pancreatic infection were involved into infection group and other 30 patients were involved into non-infection group. Serum PCTs on admission, the third day after admission, he seventh day after admission were determined by EL-MA and TNF-α and IL-8 were determined by ELISA. Results The levels of serum PCT, TNF-α and IL-8 in the SAP group were all significantly higher than those in the MAP group (P<0. 01) . The levels of serum PCT, TNF-α and IL-8 reached the peak level on the third day after admission in the two groups, but their levels in the SAP group were still significantly higher than those in the MAP group (P<0. 05) . The levels of serum PCT, TNF-α and IL-8 both reduced on the seventh day after admission, but their levels in the SAP group were still significantly higher than those in the MAP group (P<0. 05) . The levels of serum PCT on admission, the third day after admission and the seventh day after admission in the infection group were all significantly higher than those of the non-infection group (P<0. 01) . The levels of TNF-α and IL-8 on admission, the
third day after admission and the seventh day after admission in the infection group were all higher than those of the non-infection group but without statistical significance (P > 0. 05) . Conclusion TNF-α and IL-8 can be used for the diagnosis of SAP and MAP, but can not be used to judge whether there is infection. PCT can not only reflect the severity of AP, but can also judge whether there is infection at an early stage, helping choose antibody reasonably at an early stage and prevent infection. Serum PCT, TNF-α and IL-8 can be easily determined with good accuracy and low price. They can also be dynamically monitored, which is conducive to choosing more reasonable treatment by the doctor.关键词
胰腺炎/降钙素/肿瘤坏死因子α/白细胞介素8Key words
Pancreatitis/ Calcitonin/ Tumor necrosis factor-alpha/ Interleukin-8分类
医药卫生
