摘要
Abstract
Objective To investigate the effects of exercise and diet intervention on insulin resistance (IR) and serum adiponectin (ADP) and visfatin levels in patients with gestational diabetes mellitus (GDM).Methods Totally 88 pregnant women in their 24 ~ 28 gestational weeks were divided into GDM group (n = 38) and glucose tolerance in normal pregnant women (NGT) group (n = 50) based on the ADA 2009 GDM diagnostic standards.The fasting blood glucose (FBG), fasting insulin (FINS), blood lipid, ADP, and visfatin were determined.The insulin index (HOMA-IR) and body mass index (BMI) were calculated.The GDM group was provided with household-based diet intervention and exercise.All the subjects were tracked, and the above indicators were measured in the 37 ~ 40 gestational weeks.Results Before the intervention (during the mid-trimester), the levels of FBG, FINS, HOMA-IR, TG and LDL-C in the GDM group were significantly higher than in the NGT group (all P < 0.05); meanwhile, the level of visfatin was significantly higher and the ADP level significantly lower than the NGT group (all P <0.05).In addition, HOMA-IR was positively correlated with age, gestational week, TG, and visfatin levels (P <0.05), and negatively with ADP levels (P < 0.05).After the intervention (during the late pregnancy), the BMI, FBG, HOMA-IR, and visfatin were significantly higher in the GDM group than in NGT group whereas the adiponectin was significantly lower (P < 0.05) .Spearman linear analysis showed that the adiponectin level was negatively correlated with the gestational week and FBG level (P <0.05), whereas the visfatin was negatively correlated with the gestational week and FINS level (P <0.05).Conclusion Pregnant women have low ADP, high visfatin and high HOMA-IR during the mid-trimester.Exercise combined with diet intervention can effectively control blood lipid, ADP, and visfatin levels and improving insulin resistance in GDM patients.关键词
糖尿病,妊娠/胰岛素抵抗/脂联素/内脂素Key words
Diabetes, gestational/ Insulin resistance/ Adiponectin/ Visfatin分类
医药卫生
