中国全科医学2012，Vol.15Issue(30)：3498-3501,4.DOI:10.3969/j.issn.1007-9572.2012.10.096
POEMS综合征20例临床特征分析
Analysis of Clinical Features on 20 Cases of POEMS Syndrome
崔红卫 1张博爱 1刘荣利 1姬亚杰 1李星 1贾贺 1张晓敏1
作者信息
- 1. 450052,河南省郑州市,郑州大学第一附属医院神经内一科
- 折叠
摘要
Abstract
Objective To analyze and summarize the clinical features of POEMS syndrome in order to improve the recognition of POEMS syndrome and reduce misdiagnosis.Methods Clinical manifestations, auxiliary examinations, treatment and prognosis of 20 patients with POEMS syndrome admitted to our hospital were retrospectively analyzed and related literatures were also reviewed.Results All 20 patients had polyneuropathy and skin changes.18 cases had monoclonal plasmacytosis.The positive rate of serum M protein was 90.0% and the positive rate of immunofixation was up to 100.0% (17/17).12 cases were given bone marrow puncture and the average proportion of plasmocyte in bone marrow smear was 3.2% .16 cases had swelling organs, 19 cases had endocrine abnormality and 19 cases had increased water load.Renal insufficiency was common.12 cases had increased β2-microglobulin and 4 cases had increased creatinine.Other clinical features were shown as follows: 8 cases had increased pulmonary artery pressure, 10 cases had anemia, 5 cases had thrombocythemia, 2 cases had multiple skeletal a-nomalies and one case had refractory abdominal pain.The misdiagnosis rate was 95.0% , of which 8 cases were misdiagnosed as Guillain-Barre Syndrome, 4 cases were misdiagnosed as hypothyroidism and 7 cases were misdiagnosed as other medical diseases.The mortality rate was 5.0% (1/20).Conclusion POEMS syndrome has various first symptoms with complicated clinical features and could be easily misdiagnosed, causing development of the disease.Clinical doctors should deepen understanding of the disease and perform careful examinations for suspected patients to avoid misdiagnosis.关键词
POEMS综合征/临床特点/误诊Key words
POEMS syndrome/ Clinical characteristics/ Diagnostic errors分类
医药卫生引用本文复制引用
崔红卫,张博爱,刘荣利,姬亚杰,李星,贾贺,张晓敏..POEMS综合征20例临床特征分析[J].中国全科医学,2012,15(30):3498-3501,4.
