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Increased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead

Yuanyuan You Liguang Sun Bo Peng Yan Li Songbin Ben Shuang Gao

中国神经再生研究（英文版）2012，Vol.7Issue(25)：1939-1945,7.

中国神经再生研究（英文版）2012，Vol.7Issue(25)：1939-1945,7.DOI:10.3969/j.issn.1673-5374.2012.25.003

Increased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead

Yuanyuan You ¹Liguang Sun ¹Bo Peng ²Yan Li ³Songbin Ben ⁴Shuang Gao⁵

作者信息

1. Department of Biochemical and Molecular Biology, China Medical University, Shenyang 110001, Liaoning Province, China
2. Outpatient Department of China Medical University, Shenyang 110001, Liaoning Province, China
3. Department of Biochemical and Molecular Biology, Jilin Medical College, Jilin 132013, Jilin Province, China
4. School of Life Science, Liaoning University, Shenyang 110036, Liaoning Province, China
5. School of Public Health, China Medical University, Shenyang 110001, Liaoning Province, China
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摘要

Abstract

Disrupted-In-Schizophrenia 1 is a susceptibility gene for schizophrenia and other psychiatric disorders.Developmental lead exposure can cause neurological disorders similar to hyperactivity disorder,dyslexia and schizophrenia. In the present study, we examined the impact of developmental lead exposure, administered in vitro and in vivo, on hippocampal Disrupted-In- Schizophrenia 1 expression. Our results show that in cultured hippocampal neurons, in vitro exposure to 0.1-10 μM lead, inhibited neurite growth and increased Disrupted-In-Schizophrenia 1 mRNA and protein expression dose-dependently. In addition, blood lead levels in mice were increased with increasing mouse maternal lead (0.01-1 mM) exposure. Hippocampal neurons from these mice showed a concomitant increase in Disrupted-In-Schizophrenia 1 mRNA and protein expression. Overall our findings suggest that in vivo and in vitro lead exposure increases Disrupted-In-Schizophrenia 1 expression in hippocampal neurons dose-dependently, and consequently may influence synapse formation in newborn neurons.

关键词

lead exposure/ Disrupted-In-Schizophrenia 1/ hippocampus/ neuron/ neurotoxicity/ synapse/ neural regeneration

Key words

lead exposure/ Disrupted-In-Schizophrenia 1/ hippocampus/ neuron/ neurotoxicity/ synapse/ neural regeneration

引用本文复制引用

Yuanyuan You,Liguang Sun,Bo Peng,Yan Li,Songbin Ben,Shuang Gao..Increased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead[J].中国神经再生研究（英文版）,2012,7(25):1939-1945,7.

基金项目

This work was supported by the National Nature Science Foundation of China,No.39970651,and a Foundation from China Medical University. （）

中国神经再生研究（英文版）

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ISSN：1673-5374

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