首页|期刊导航|中国神经再生研究（英文版）|The norepinephrine transporter gene is associated with the retardation symptoms of major depressive disorder in the Han Chinese population
中国神经再生研究（英文版）2012，Vol.7Issue(25)：1985-1991,7.DOI:10.3969/j.issn.1673-5374.2012.25.010
The norepinephrine transporter gene is associated with the retardation symptoms of major depressive disorder in the Han Chinese population
The norepinephrine transporter gene is associated with the retardation symptoms of major depressive disorder in the Han Chinese population
摘要
Abstract
The norepinephrine transporter plays an important role in the pathophysiology and pharmacological treatment of major depressive disorder. Consequently, the norepinephrine transporter gene is an attractive candidate in major depressive disorder research. In the present study, we evaluated the depression symptoms of subjects with major depressive disorder, who were all from the North of China and of Han Chinese origin, using the Hamilton Depression Scale. We examined the relationship between two single nucleotide polymorphisms in the norepinephrine transporter, rs2242446 and rs5569, and the retardation symptoms of major depressive disorder using quantitative trait testing with the UNPHASED program. rs5569 was associated with depressed mood, and the GG genotype may be a risk factor for this; rs2242446 was associated with work and interest, and the TT genotype may be a risk factor for loss of interest. Our findings suggest that rs2242446 and rs5569 in the norepinephrine transporter gene are associated with the retardation symptoms of depression in the Han Chinese population.关键词
Norepinephrine transporter/ major depressive disorder/ quantitative trait locus/ gene polymorphism/retardation symptoms/ Hamilton Depression Scale/ endophenotype/ single nucleotide polymorphism/pathogenesisKey words
Norepinephrine transporter/ major depressive disorder/ quantitative trait locus/ gene polymorphism/retardation symptoms/ Hamilton Depression Scale/ endophenotype/ single nucleotide polymorphism/pathogenesis引用本文复制引用
Xinrong Li,Ning Sun,Yong Xu,Yanfang Wang,Suping Li,Qiaorong Du,Juyi Peng,Jinxiu Luo,Kerang Zhang..The norepinephrine transporter gene is associated with the retardation symptoms of major depressive disorder in the Han Chinese population[J].中国神经再生研究（英文版）,2012,7(25):1985-1991,7.基金项目
This project was supported by the National Natural Science Foundation of China,No.30770770,30971054,and 81171290 （）
Science Foundation for the Youth of Shanxi,No.2011021036-1. （）
