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Brain-derived neurotrophic factor expression in dorsal root ganglion neurons in response to reanastomosis of the distal stoma after nerve grafting

Wei Yu Jian Wang Mingzhu Xu Hanjiao Qin Shusen Cui

中国神经再生研究（英文版）2012，Vol.7Issue(26)：2012-2017,6.

中国神经再生研究（英文版）2012，Vol.7Issue(26)：2012-2017,6.DOI:10.3969/j.issn.1673-5374.2012.26.002

Brain-derived neurotrophic factor expression in dorsal root ganglion neurons in response to reanastomosis of the distal stoma after nerve grafting

Wei Yu ¹Jian Wang ²Mingzhu Xu ³Hanjiao Qin ⁴Shusen Cui¹

作者信息

1. Department of Hand Surgery,China Japan Union Hospital,Jilin University,Changchun 130033,Jilin Province,China
2. Department of Orthopedics,First Affiliated Hospital,Wenzhou Medical College,Wenzhou 325000,Zhejiang Province,China
3. Department of Nephrology,China Japan Union Hospital,Jilin University,Changchun 130033,Jilin Province,China
4. Norman Bethune Medical College,Jilin University,Changchun 130021,Jilin Province,China
折叠

摘要

Abstract

Studies have shown that retreatment of the distal stoma after nerve grafting can stimulate nerve regeneration. The present study attempted to verify the effects of reanastomosis of the distal stoma, after nerve grafting, on nerve regeneration by assessing brain-derived neurotrophic factor expression in 2-month-old rats. Results showed that brain-derived neurotrophic factor expression in L2-4 dorsal root ganglia began to increase 3 days after autologous nerve grafting post sciatic nerve injury, peaked at 14 days, decreased at 28 days, and reached similar levels to the sham-surgery group at 56 days. Brain-derived neurotrophic factor expression in L2-4 dorsal root ganglia began to increase 3 days after reanastomosis of the distal stoma, 59 days after autologous nerve grafting post sciatic nerve injury, significantly increased at 63 days, peaked at 70 days, and gradually decreased thereafter, but remained higher compared with the sham-surgery group up to 112 days. The results of this study indicate that reanastomosis of the distal stoma after orthotopic nerve grafting stimulated brain-derived neurotrophic factor expression in L2-4 dorsal root ganglia.

关键词

sciatic nerve/orthotopic nerve grafting/brain-derived neurotrophic factor/dorsal root ganglion/distal stoma/reanastomosis/peripheral nerve injury/neural regeneration

Key words

sciatic nerve/orthotopic nerve grafting/brain-derived neurotrophic factor/dorsal root ganglion/distal stoma/reanastomosis/peripheral nerve injury/neural regeneration

引用本文复制引用

Wei Yu,Jian Wang,Mingzhu Xu,Hanjiao Qin,Shusen Cui..Brain-derived neurotrophic factor expression in dorsal root ganglion neurons in response to reanastomosis of the distal stoma after nerve grafting[J].中国神经再生研究（英文版）,2012,7(26):2012-2017,6.

基金项目

This study was supported by the Key Project of Clinical Subject of the Health Ministry,China (2010-2012),No.[2010]439. （2010-2012）

中国神经再生研究（英文版）

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ISSN：1673-5374

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