首页|期刊导航|中国神经再生研究（英文版）|Is the C677T polymorphism in methylenetetrahydrofolate reductase gene or plasma homocysteine a risk factor for diabetic peripheral neuropathy in Chinese individuals?
中国神经再生研究（英文版）Issue(30)：2384-2391,8.DOI:10.3969/j.issn.1673-5374.2012.30.009
Is the C677T polymorphism in methylenetetrahydrofolate reductase gene or plasma homocysteine a risk factor for diabetic peripheral neuropathy in Chinese individuals?
Is the C677T polymorphism in methylenetetrahydrofolate reductase gene or plasma homocysteine a risk factor for diabetic peripheral neuropathy in Chinese individuals?
摘要
Abstract
The present study enrolled 251 diabetic patients,including 101 with neuropathy and 150 without neuropathy.Of the 150 patients,100 had no complications,such as retinopathy,nephropathy,or neuropathy.Polymerase chain reaction-restriction fragment length polymorphism analysis was used to identify methylenetetrahydrofolate reductase gene variants.Plasma homocysteine levels were also measured.Homocysteine levels and the frequency of hyperhomocysteinemia were significantly higher in patients with diabetic peripheral neuropathy compared with diabetic patients without neuropathy (P ＜ 0.05).In logistic regression analysis with neuropathy as the dependent variable,the frequency of C677T in methylenetetrahydrofolate reductase was significantly higher in patients with diabetic peripheral neuropathy compared with patients without diabetic complications.Homocysteine levels were significantly higher in patients with diabetic peripheral neuropathy carrying the 677T allele and low folic acid levels.In conclusion,hyperhomocysteinemia is an independent risk factor for diabetic neuropathy in Chinese patients with diabetes.The C677T polymorphism in methylenetetrahydrofolate reductase and low folic acid levels may be risk factors for diabetic peripheral neuropathy in Chinese patients with diabetes.关键词
homocysteine/ methylenetetrahydrofolate reductase/ type 2 diabetes mellitus/ diabetic peripheral neuropathy/ neural regenerationKey words
homocysteine/ methylenetetrahydrofolate reductase/ type 2 diabetes mellitus/ diabetic peripheral neuropathy/ neural regeneration引用本文复制引用
Hongli Wang,Dongsheng Fan,Tianpei Hong..Is the C677T polymorphism in methylenetetrahydrofolate reductase gene or plasma homocysteine a risk factor for diabetic peripheral neuropathy in Chinese individuals?[J].中国神经再生研究（英文版）,2012,(30):2384-2391,8.基金项目
The study was supported by the Natural Science Foundation of Beijing,No.7102161. （）
