中国比较医学杂志2012，Vol.22Issue(9)：31-35,5.DOI:10.3969.j.issn.1671.7856.2012.009.007
实验性高脂血症恒河猴模型的初步建立及分析
Establishment and Analysis of Experimental Hyperlipidemia Model in Rhesus Monkey
摘要
Abstract
Objective To establish Rhesus monkey model of hyperlipidemia to provide reliable animal model for the study of human hyperlipidemia. Methods Designed high fat experimental feed formulations and detected its nutrients to feed Rhesus monkey to arouse hyperlipidemias. 2 mouths、4 mouths、6mouths later, we monitored the body weight, serum total cholesterol ( TC ) , triglyceride ( TG ) , high-density lipoprotein cholesterol ( HDL-C ) , low density lipoprotein cholesterol ( LDL-C) ,and analyzed the trend of each index above. Results When it was 2 moths and 4 months later,the feed intake and energy intake of model group were lower than control group(P <0. 05) , but the body weight of model group was not significantly different from that of the control group( P > 0. 05 ) ; When it was 6 moths, the feed intake and energy intake of model group was not significantly different from that of the control group, and the body weight of model group were significantly different from that of the control group ( P < 0. 05 ) ; When it was 2 moths later, the indexes of TC, TG, HDL-C and LDL-C of the model group were not significantly different from that of the control group ( P > 0. 05 ). When it was 4 moths later,the indexes of TC ,TG, LDL-C of the model group were significantly different from that of the control group( P < 0. 05 ). When it was 6 moths later, the indexes of TC, LDL-C of the model group were significantly different from that of the control group(P < 0. 05 ) , and much higher than the normal levels, but the indexes of TG,HDL-C were not significantly different from that of the control group ( P > 0. 05 ). According to the monitoring, TC and LDL-C showed a increase trend, TG showed a gradual recovery after the first descending trend, and the HDL-C was not significantly changed. Conclusion Rhesus monkeys of the model group has a feature of high cholesterol and high low-density lipoprotein cholesterol. The paper has initialy established Rhesus monkey model of experimental hyperlipidemia.关键词
血脂/高脂血症/模型,动物/恒河猴Key words
Lipid/ Hyperlipidemia/ Model, animal/ Rhesus monkey分类
医药卫生引用本文复制引用
杨凤梅,李艳艳,鲁帅尧,赵远,禹文海,陈丽雄,王俊斌,和占龙..实验性高脂血症恒河猴模型的初步建立及分析[J].中国比较医学杂志,2012,22(9):31-35,5.基金项目
云南省技术创新人才培养基金(2009C1117) （2009C1117）
云南省应用基础研究面上项目资助课题(2009ZC185M). （2009ZC185M）
