中国兽医科学2012，Vol.42Issue(8)：861-864,4.
米尔贝肟对犬钩虫的体外作用
In vitroanthelmintic sensitivity of milbemycin oxime to Ancylostoma caninum
摘要
Abstract
Anthelmintic sensitivity of milbemycin oxime to Ancylostoma caninum in vitrowas studied.Milbemycin oxime groups with concentrations of 1×10-5,1×10-6,1×10-7,1×10-8 and 1×10-9 g/mL respectively,as well as ivermectin group and control group were adopted to detect effects of milbemycin oxime on the morphology of quiescent larvae,larval motility and larval migration.It showed that most larvae under drug-free conditions assumed a straight morphology,free from deviations,and kinking or coiling.However,in subsequent drug-exposed wells,an increasing proportion of quiescent larvae had major deviations（kinking） at angles of greater than 45°,and these deviations involved a greater portion of the body than those associated with normally quiescent larvae under control conditions.Anthelmintic rate of milbemycin oxime can achieve 100% in the 8th hour at concentration of 1×10-5 g/mL,and milbemycin oxime has the same effects with ivermectin at the concentration of 1×10-6 g/mL（P0.05）.Both milbemycin oxime and ivermectin had significant inhibitory effects on larval motility.In conclusion,Ancylostoma caninum is sensitive to milbemycin oxime.关键词
犬钩虫/米尔贝肟/体外敏感性Key words
Ancylostoma caninum/milbemycin oxime/in vitro sensitivity分类
农业科技引用本文复制引用
徐倩倩,李继昌,郭时金,沈志强..米尔贝肟对犬钩虫的体外作用[J].中国兽医科学,2012,42(8):861-864,4.基金项目
“十一五”国家科技支撑计划项目 （）
