摘要
Abstract
Objective: To investigate the clinical features of patients with treatment-resistant schizophrenia, and to explore the related factors of treatment-resistant schizophrenics and course of disease. Methods: The discharge records of 404 inpatients who were diagnosed as schizophrenia from January 1, 2009 to December 31, 2009 were analyzed retrospectively. The treatment-resistant schizophrenics were defined as patients who were aged I860 years old, had not achieved the clinical recovery, after 3 or more antipsychotics treatment in sufficient quantities and sufficient course or could not tolerate the adverse drug reaction. Related factors were compared between treatment-resistant and non-resistant schizophrenics, also among the treatment-resistant schizophrenics. Results: Compared with non-resistant schizophrenics (n =312), patients with treatment-resistant schizophrenia (n =92) had younger age at onset [(21 ±7) years vs. (25 ±9) years, P <0.05], longer course of disease [(9 ± 13) a vs. (6 ±7) a,P<0. 05],had more times of hospitalization [(2 ±3) vs. (1 ± 1), P <0. 05], longer of hospitalization [(69 ± 48) d vs. (52 ±44) d, P <0- 05], Multiple regression analysis showed male ( OR = 1. 72), history of stopping medication (OR = 1. 82), positive family history (OR = 1. 91) patients were more likely to be treatment-resistant schizophrenics, (Ps <0.05). In the sample of treatment-resistant schizophrenics, patients with 5 or more years course had older age [(37 ±11) years vs. (22 ±4) years] and older age at onset [(22 ±8) years vs. (17 ± 2) years, P < 0.05], and higher married proportion (27. 5% vs. 4. 3%, P <0.05) than the ones with course of less than 5 years, we found no difference in other factors. Conclusion: Male, positive family history, incompliance to medication may be the risk factors for treatment-resistant schizophrenia It is worth to take further study on whether the course of disease in the definition of treatment-resistant schizophrenia is more than five years.关键词
难治性精神分裂症/相关因素/病程/回顾性研究Key words
treatment-resistant schizophrenia/ related factor/ clinical course/ retrospective study
分类
医药卫生
