中国心理卫生杂志2012，Vol.26Issue(9)：669-675,7.DOI:10.3969/j.issn.1000-6729.2012.09.006
强迫症与5-羟色胺转运体基因多态性遗传关联病例对照研究的meta分析
Genetic association of obsessive-compulsive disorder and serotonin transporter gene polymorphisms: A meta-analysis of data from case-control studies
摘要
Abstract
Objective: To evaluate the association of obsessive-compulsive disorder (OCD) and intron 2 (5-HTTVNTR)and promoter (5-HTTLPR) of SLC6A4 gene polymorphism with meta-analysis and provide evidence for the genetic background of OCD. Methods: We searched for the related case-control designed studies of association between OCD and serotonin transporter gene polymorphisms. The allele and genotype frequencies were extracted from each study, and the pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated to evaluate the allele and genotype of OCD and controls by using software CMA 2. 0. Results: The data from 23 studies were involved in the meta-analysis. The meta-analysis results of association of OCD with the serotonin transporter (5-HTT) gene LPR and VNTR polymorphisms had led to controversial results in different populations. In Asian population, the frequencies of allele L (vs. allele S, OR = 1. 27,95% CI = 1. 05 - 1. 52), genotype LL[ vs. genotype (LS + SS), OR = 1. 78,95% CI = 1. 15 - 2. 74] were higher in OCD patients than those in the controls. In Caucasian population, the frequencies of genotype SS [vs. genotype (LS + SS), OR = 1. 21,95% CI = 1. 02 - 1. 44] were lower. In Caucasian population, the frequencies of genotype 10/10 (vs. genotype10/12 + 12/12, OR =0.41,95% CI = 0. 24 -0. 71) were lower in OCD patients than those in the controls. Conclusion: The findings suggest there be association of OCD and 5-HTT gene polymorphisms. The 5-HTTLPR gene allele L and genotype LL may be risk factors and genotype SS may be protection factor among Asians, while 5-HTTLPR genotype SS may be risk factor and 5-HTTVNTR genotype 10/10 may be protection factor for OCD among Caucasians.关键词
强迫症/5-HTTLPR/5-HTTVNTR/基因多态性/meta分析Key words
obsessive-compulsive disorder/ promoter of 5- Serotonin Transporter Gene Polymorphism/ genotype of intron2 of 5-Serotonin Transporter Gene Polymorphism/ gene polymorphism/ meta-analysis
分类
医药卫生引用本文复制引用
何小燕,马梁红,李存超,王睿..强迫症与5-羟色胺转运体基因多态性遗传关联病例对照研究的meta分析[J].中国心理卫生杂志,2012,26(9):669-675,7.
