中国药房2012，Vol.23Issue(33)：3081-3083,3.DOI:10.6039/j.issn.1001-0408.2012.33.04
头孢呋辛钠的热稳定性及其热分解动力学研究
Thermal Stability and Kinetics of Thermal Decomposition for Cefuroxime Sodium
摘要
Abstract
OBJECTIVE: To study the thermal stability of cefuroxime sodium. METHODS: The thermal decomposition curves were determined by thermogravimetry (TG) analysis and differential scanning calorimetry (DSC). A combined method, including Kissinger method and Ozawa-Flynn-Wall method, was put forward to determining the kinetic parameters of thermal decomposition of cefuroxime sodium. RESULTS: The kinetic parameters of cefiiroxime sodium by Kissinger method vs. Ozawa-Flynn-Wall method were as follows: apparent activation energy: 139.2 kJ·mol-1 vs. 139.3 kJ·mol-1 and preexponential factor (In value): 18.64 s-1 vs. 18.66 s-1 in air; apparent activation energy: 106.8 kJ·mol-1 vs. 108.5 kJ·mol-1 and In value: 14.64 s-1 vs. 14.85 s-1 in nitrogen. There was no significant difference between 2 methods. CONCLUSION: Cefuroxime sodium has high activation energy with good thermal stability, and has better stability in nitrogen than in air.关键词
头孢呋辛钠/热稳定性/热分解动力学/热重分析法/差式扫描量热法Key words
Cefuroxime sodium/ Thermal stability/ Kinetics of thermal decomposition/ Thermogravimetry analysis/ Differential scanning calorimetry分类
医药卫生引用本文复制引用
赵龙山,李清,陈晓辉,毕开顺..头孢呋辛钠的热稳定性及其热分解动力学研究[J].中国药房,2012,23(33):3081-3083,3.基金项目
国家重大新药创制科技重大专项(2009ZX09301-012) （2009ZX09301-012）
