中国药房2012，Vol.23Issue(34)：3226-3228,3.DOI:10.6039/j.issn.1001-0408.2012.34.20
盐酸帕洛诺司琼用于麻醉术后止吐的效果观察
Therapeutic Observation of Palonosetron Hydrochloride for Vomiting after Anesthesia Surgery
赵建生 1佟波涛1
作者信息
- 1. 解放军第81医院麻醉科,南京210002
- 折叠
摘要
Abstract
OBJECTIVE: To observe therapeutic efficacy and adverse drug reaction of palonosetron hydrochloride for acute and delayed vomiting after anesthesia surgery. METHODS: 60 patients with laparoscopic cholecystectomy were randomly divided into test group and control group with 30 patients in each group. Before induction of anesthesia, test group was given palonosetron hydrochloride 0.25 mg and control group was given tropisetron hydrochloride 5 mg. Antiemetic effects and adverse drug reactions of 2 groups were recorded within 72 h after surgery. RESULTS: The complete control rates of acute vomiting in test group and control group after anesthesia surgery were 80.0% and 70.0% respectively (P＞0.05), the incidence of acute vomiting was 13.3% and that of delayed vomiting were 6.7% and 16.7% respectively (P＜0.05); main adverse drug reactions were bloating, headache and constipation in 2 groups and the incidences of adverse drug reaction were 23.3% and 20.0% (P＞0.05). CONCLUSION: These two 5-HT3 receptor antagonists both have good antiemetic effect, but palonosetron hydrochloride is better in the treatment of delayed vomiting.关键词
盐酸帕洛诺司琼/盐酸托烷司琼/恶心/呕吐/麻醉/药物疗效Key words
Palonosetron hydrochloride/ Tropisetron hydrochloride/ Nausea/ Vomiting/ Anesthesia/ Therapeutic efficacy分类
医药卫生引用本文复制引用
赵建生,佟波涛..盐酸帕洛诺司琼用于麻醉术后止吐的效果观察[J].中国药房,2012,23(34):3226-3228,3.
