中国药理学与毒理学杂志2012，Vol.26Issue(4)：499-503,5.DOI:10.3867/j.issn.1000-3002.2012.04.006
三七总皂苷对大鼠心肌缺血的保护作用
Protective effect of Panax notoginseng saponins on acute myocardial ischemia in rats
摘要
Abstract
OBJECTIVE To explore the effect of Panax notoginseng saponins ( PNS) pre-treatment on acute myocardial ischemia in rats. METHODS The rats were ig given PNS 0, 25 , 50, 100, 200, 400, 600 and 800 mg·kg-1, twice a day, for7 times. After the last administration for 30 min, the acute myocardial ischemia model was induced by left anterior descending coronary artery ligation. The percentage of the myocardial infarct size was determined by TTC staining after 24 h, and left ventricular carotid artery blood flow dynamics was monitored by a biological signal acquisition and analysis system. Meanwhile, the cardiac enzymes related to myocardial infarction were assayed by an automatic biochemical analyzer. RESULTS Compared with model group, PNS 50, 100, 200 and 400 mg·kg-1 pretreatment significantly reduced infarct size in myocardial ischemia rats, decreased left ventricular end-diastolic pressure, improved left ventricular systolic pressure , and increased the maximum rate of increase/decrease in left ventricular pressure. Serum levels of lactate dehydrogenase and creatine kinase were significantly lowered; a- hydroxybutyrate dehydro-genase and aspartate aminotransferase were also obviously decreased. CONCLUSION PNS 50 -400 mg·kg-1 could significantly reduce myocardial infarct size, improve left ventricular diastolic and systolic function and inhibit the release of myocardial enzymes.关键词
三七总皂苷/心肌缺血/左心室功能/心肌酶Key words
Panax nologinseng saponins/myocardial ischemia/left ventricular function/cardiac enzymes分类
医药卫生引用本文复制引用
韩淑燕,马旭,李海霞,张可,屠鹏飞..三七总皂苷对大鼠心肌缺血的保护作用[J].中国药理学与毒理学杂志,2012,26(4):499-503,5.基金项目
国家杰出青年基金资助课题(30525043) （30525043）
