中国药业2012，Vol.21Issue(18)：19-20,2.
羟基红花黄色素A冻干粉针剂对血小板活化因子致大鼠脑皮质线粒体损伤的保护作用
Protective Effect of HSYA Freeze-Dried Powder in Rats' Brain Cortex Mitochondria PAF-induced Injury
徐露 1董志1
作者信息
- 1. 重庆医科大学药学院·重庆市生化与分子药理重点实验室,重庆 400016
- 折叠
摘要
Abstract
Objective To investigate the protective effect of hydroxysafflor yellow A (HSYA) freeze - dried powder on platelet activating factor(PAF) induced rat brain cortex mitochondria damage. Methods PAF as the inducing agent was adopted to perform the in vitro damage experiment of isolated rat brain cortex mitochondria. The injuried mitochondria were given HSYA for incubation. The mitochon-drial membrane fluidity, swelling and content change of SOD and MDA before and after experiment were observed. Results PAF could reduce the mitochondrial membrane fluidity, increase mitochondrial swelling, decrease the content of SOD and increase the content of MDA. After given different doses of HSYA,the mitochondrial membrane fluidity was increased,mitochondrial membrane swelling was decreased , SOD content was increased and MDA content was decreased. Conclusion PAF could impair the structure and function of rat brain cortex mitochondria, but HSYA freeze - dried powder has significant protective effect.关键词
羟基红花黄色素A/线粒体/血小板活化因子Key words
HSYA/ mitochondria/ PAF分类
医药卫生引用本文复制引用
徐露,董志..羟基红花黄色素A冻干粉针剂对血小板活化因子致大鼠脑皮质线粒体损伤的保护作用[J].中国药业,2012,21(18):19-20,2.
