中国真菌学杂志2012，Vol.7Issue(3)：132-135,4.
(1,3)-β-D-葡聚糖检测和半乳甘露聚糖抗原检测在侵袭性真菌病诊断中的价值探讨
Detection of (1,3)-β-D-Glucan and Galactomannan for diagnosis of invasive fungal disease
摘要
Abstract
Objective To evaluate the non-culture diagnostic methods for diagnosis of invasive fungal disease (IFD). Methods A retrospective study was performed on hospitalized patients of Peking University First Hospital who were at risk of IFD. The diagnosis of invasive fungal infection was according to revised definitions. Non-culture methods including galactomannan emzyme immuno-assay (GM test)and (1,3)-β-D-glucan assay (G test) were analysed of sensitivity, specificity, and concordance rate, respectively. Two tests were combined to evaluate the changes of sensitivity, specificity, and concordance rate. Results The sensitivity and specificity were 70% , 84% in GM test; 50% , 92% in G test; and 93% , 78% in combined utility of two tests. Conclusions The GM test and G test were both useful in diagnosis of IFD. The better sensitivity and concordance rate might be acquired by combining these two tests.关键词
侵袭性真菌病/诊断/半乳甘露聚糖,(1,3)-β-D-葡聚糖Key words
IFD/ diagnosis/ galactomannan ,(1,3) -β-D-glucan分类
医药卫生引用本文复制引用
郑罡,余进,李雪迎,万喆,李若瑜..(1,3)-β-D-葡聚糖检测和半乳甘露聚糖抗原检测在侵袭性真菌病诊断中的价值探讨[J].中国真菌学杂志,2012,7(3):132-135,4.基金项目
卫生部部属(管)医院2010-2012年度临床学科重点项目基金(2010-2012) （管）
艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2008ZX1004-002) （2008ZX1004-002）
