中国真菌学杂志2012，Vol.7Issue(3)：178-183,6.
白念珠菌生物被膜基质研究进展
Advances in the matrix of Candida albicans biofilms
摘要
Abstract
Recently, more and more attention was being paid to resistance of Candida albicans to antifungal drugs. One of the resistance mechanisms was attributed to biofilm formation. The biofilms strongly attached to biologic or nonbiologic substrata were mainly made up of communities of microorganisms enclosed within a self-produced extracellular matrix. Consisting of polysaccha-rides, proteins, nucleic acids, etc. the matrix is not only involved in biofilm structure formation but also closely related to the resistance to therapeutic agents. This review focused on recent information about chemical compositions and properties, functions, influencing factors, gene regulation, and drug treatment of biofilm matrix, and discussed its potential applications as diagnostic marker and therapeutic target.关键词
白念珠菌/生物被膜/基质/耐药性Key words
Candida albicans / biofilms/ matrix/ resistance分类
医药卫生引用本文复制引用
汪长中,邵菁,汪天明,程惠娟..白念珠菌生物被膜基质研究进展[J].中国真菌学杂志,2012,7(3):178-183,6.基金项目
国家自然科学基金(81073127),安徽省自然科学基金(090413092),安徽省高校省级自然科学研究重点项目(KJ2010A220) （81073127）
