中华医学杂志（英文版）2012，Vol.125Issue(16)：2826-2831,6.DOI:10.3760/cma.j.issn.0366-6999.2012.16.005
Acute responses to inhalation of Iloprost in patients with pulmonary hypertension
Acute responses to inhalation of Iloprost in patients with pulmonary hypertension
ZHANG Hong-liang 1SUN Xing-guo 2LIU Zhi-hong 1WANG Yong 1XIONG Chang-ming 1NI Xin-hai 1HE Jian-guo 1LUO Qin 1ZHAO Zhi-hui 1ZHAO Qing1
作者信息
- 1. Center for Pulmonary Vascular Diseases,State Key Laboratory of Cardiovascalar Disease, Fuwai Hospital,National Center for Cardiovascalar Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,100037, China
- 2. Laboratory of Cardiopulmonary Exercise Testing,State Key Laboratory of Cardiovascalar Disease, Fuwai Hospital,National Center for Cardiovascalar Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,100037, China
- 折叠
摘要
Abstract
Background Iloprost has been used to test acute pulmonary vasoreactivity in idiopathic pulmonary arterial hypertension (PAH).We aimed to investigate the acute hemodynamic and oxygenation responses and tolerability to 20 μg aerosolized Iloprost in Chinese patients with pulmonary hypertension.Methods Between March 2005 and May 2010,212 pulmonary hypertension patients inhaled a single dose of 20 μg Iloprost over 10-15 minutes for vasoreactivity testing.The acute hemodynamic and oxygenation responses and adverse events were recorded.Results lioprost decreased total pulmonary resistance ((1747±918) dyn.s.cm-5 vs.(1581±937) dyn.s.cm-5,P ＜0.001),increased stroke volume ((45.0±22.1) ml vs.(47.0±24.2) ml,P=0.002),and cardiac output ((3.7±1.7) L/ml vs.(3.9±1.9)L/min,P=0.009).Heart rate and systemic vascular resistance remained stable during inhalation.However,systemic arterial blood oxygen saturation fell slightly ((91.0±6.8)％ vs.(90.3±6.7)％,P=0.002).Pulmonary and systemic arterial blood pressures declined within 1-3 minutes after inhalation initiation and reached their lowest levels within 10-15 minutes.Idiopathic PAH responded more favorably than pulmonary hypertension due to other causes (P≤0.001) and patients with less severe pulmonary hypertension have better responses to Iloprost.No adverse events requiring medical care or leading to termination of inhalation occurred.Conclusions Inhalation of 20 μg Iloprost showed potent and selective pulmonary hemodynamic effects and was well tolerated in the Chinese pulmonary hypertension patients.Patients with idiopathic PAH and less severe pulmonary hypertension responded more favorably to inhalation of Iloprost.关键词
pulmonary hypertension/pulmonary arterial hypertension/Iloprost/hemodynamicsKey words
pulmonary hypertension/pulmonary arterial hypertension/Iloprost/hemodynamics引用本文复制引用
ZHANG Hong-liang,SUN Xing-guo,LIU Zhi-hong,WANG Yong,XIONG Chang-ming,NI Xin-hai,HE Jian-guo,LUO Qin,ZHAO Zhi-hui,ZHAO Qing..Acute responses to inhalation of Iloprost in patients with pulmonary hypertension[J].中华医学杂志（英文版）,2012,125(16):2826-2831,6.
