中华医学杂志（英文版）2012，Vol.125Issue(16)：2841-2845,5.DOI:10.3760/cma.j.issn.0366-6999.2012.16.008
Loss of membranous carcinoembryonic antigen-related cell adhesion molecule 1 expression is related to decreased relapse-free survival of hepatocellular carcinoma following liver transplantation
Loss of membranous carcinoembryonic antigen-related cell adhesion molecule 1 expression is related to decreased relapse-free survival of hepatocellular carcinoma following liver transplantation
SHA Qing-quan 1WEI Oi-zhen 2ZHU Jian-kang 2WANG Ke-xin 2WANG Chao 2LIU Hai-tao 3YU Wen-bin 2LI Ming-xia 4ZHANG Guang-yong2
作者信息
- 1. Department of Clinical Medicine, Shandong University School of Medicine, Jinan, Shandong 250012, China
- 2. Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China
- 3. First People's Hospital of Ningyang County, Tai'an, Shandong 271400, China
- 4. School of Chemistry, Shandong University, Jinan, Shandong 250012, China
- 折叠
摘要
Abstract
Background Loss of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) expression is an adverse prognostic factor in hepatocellular carcinoma (HCC).The purpose of this study was to investigate the expression of CEACAM1 and its effect on relapse-free survival (RFS) following liver transplantation (LT) for HCC.Methods Expression of CEACAM1 was immunohistochemically detected in HCC specimens from 48 patients.The relationship between CEACAM1 expression and clinicopathologic variables,as well as tumor recurrence,was further analyzed.Results Of the 48 HCC specimens,membranous CEACAM1 expression was detected in 25 specimens and cytoplasmic CEACAM1 expression was detected in 19 specimens.Four specimens had loss of CEACAM1 expression.Loss of membranous CEACAM1 expression was significantly associated with tumor size,tumor number,and serum α-fetoprotein levels (all P ＜0.05).Patients with loss of membranous CEACAM1 had significantly poorer RFS than patients with membranous expression,determined via Kaplan-Meier analysis (P=0.027).Multivariate analysis revealed that loss of membranous CEACAM1 expression might be an independent prognostic factor of RFS for HCC patients after liver transplantation (P=0.037).Conclusion Loss of membranous CEACAM1 expression in HCC was closely associated with aggressive tumor biology and might be a relapsing biomarker of HCC treated with LT.关键词
carcinoembryonic antigen-related cell adhesion molecule I/hepatocellular carcinoma/liver transplantation/recurrenceKey words
carcinoembryonic antigen-related cell adhesion molecule I/hepatocellular carcinoma/liver transplantation/recurrence引用本文复制引用
SHA Qing-quan,WEI Oi-zhen,ZHU Jian-kang,WANG Ke-xin,WANG Chao,LIU Hai-tao,YU Wen-bin,LI Ming-xia,ZHANG Guang-yong..Loss of membranous carcinoembryonic antigen-related cell adhesion molecule 1 expression is related to decreased relapse-free survival of hepatocellular carcinoma following liver transplantation[J].中华医学杂志（英文版）,2012,125(16):2841-2845,5.
