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Gastro-protecting effect of gefarnate on chronic erosive gastritis with dyspeptic symptoms

DU Yi-qi GAO Li CAI Quan-cai LI Zhao-shen SU Tun HAO Jian-yu WANG Bang-mao CHEN Min-hu LI You-ming TANG Cheng-wei GONG Yan-fang MAN Xiao-hua

中华医学杂志（英文版）2012，Vol.125Issue(16)：2878-2884,7.

中华医学杂志（英文版）2012，Vol.125Issue(16)：2878-2884,7.DOI:10.3760/cma.j.issn.0366-6999.2012.16.015

Gastro-protecting effect of gefarnate on chronic erosive gastritis with dyspeptic symptoms

DU Yi-qi ¹GAO Li ²CAI Quan-cai ¹LI Zhao-shen ¹SU Tun ¹HAO Jian-yu ³WANG Bang-mao ⁴CHEN Min-hu ⁵LI You-ming ⁶TANG Cheng-wei ⁷GONG Yan-fang ¹MAN Xiao-hua¹

作者信息

1. Department of Gastroenterology , Changhai Hospital, Second Military Medical University, Shanghai 200433, China
2. Department of Pathology,Changhai Hospital, Second Military Medical University, Shanghai 200433, China
3. Department of Gastroenterology, Beijing Chaoyang Hospital,Capital Medical University, Beijing 100020, China
4. Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, China
5. Department of Gastroenterology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
6. Department of Gastroenterology, Zhejiang First Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003,China
7. Department of Gastroenterology. West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
折叠

摘要

Abstract

Background The role of gastro-protecting agents on symptomatic chronic gastritis is unclear.This multicenter,open,randomized trial was designed to compare the comprehensive effects of gefarnate with sucralfate on erosive gastritis with dyspeptic symptoms.Methods Totally 253 dyspepsia patients confirmed with erosive gastritis were enrolled from six centers in China.They randomly received either daily 300 mg gefarnate or 3 g sucralfate for six weeks.The primary endpoint was the effective rate of both treatments on endoscopic erosion at week six.Results Gefarnate showed an effective rate of 72％ and 67％ on endoscopic score and dyspeptic symptom release,which is statistically higher than sucralfate (40.1％ and 39.3％,P ＜0.001,intension-to-treat).For histological improvement,gefarnate showed both effective in decreasing mucosal chronic inflammation (57.7％ vs.24.8％,P ＜0.001,intension-to-treat) and active inflammation (36.4％ vs.23.1％,P ＜0.05,intension-to-treat) than the control.A significant increase of prostaglandins and decrease of myeloperoxidase in mucosa were observed in gefarnate group.Severity of erosion is non-relevant to symptoms but Helicobacter pylori (H.pylori) status does affect the outcome of therapy.Conclusions Gefarnate demonstrates an effective outcome on the mucosal inflammation in patients with chronic erosive gastritis.Endoscopic and inflammation score should be the major indexes used in gastritis-related trials.

关键词

gefarnate/gastritis/functional dyspepsia/gastro-protection

Key words

gefarnate/gastritis/functional dyspepsia/gastro-protection

引用本文复制引用

DU Yi-qi,GAO Li,CAI Quan-cai,LI Zhao-shen,SU Tun,HAO Jian-yu,WANG Bang-mao,CHEN Min-hu,LI You-ming,TANG Cheng-wei,GONG Yan-fang,MAN Xiao-hua..Gastro-protecting effect of gefarnate on chronic erosive gastritis with dyspeptic symptoms[J].中华医学杂志（英文版）,2012,125(16):2878-2884,7.

基金项目

This study was supported by a grant of National Science & Technology Major Project (No.2012ZX09303-011-002). （No.2012ZX09303-011-002）

中华医学杂志（英文版）

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ISSN：0366-6999

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