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Vasculogenic mimicry is a key prognostic factor for laryngeal squamous cell carcinoma: a new pattern of blood supply

LIN Peng WANG Wei SUN Bao-cun CAI Wen-juan LI Li LU Hong-hua HAN Chun-rong ZHANG Jin-mei

中华医学杂志（英文版）2012，Vol.125Issue(19)：3445-3449,5.

中华医学杂志（英文版）2012，Vol.125Issue(19)：3445-3449,5.DOI:10.3760/cma.j.issn.0366-6999.2012.19.016

Vasculogenic mimicry is a key prognostic factor for laryngeal squamous cell carcinoma: a new pattern of blood supply

LIN Peng ¹WANG Wei ¹SUN Bao-cun ²CAI Wen-juan ²LI Li ¹LU Hong-hua ¹HAN Chun-rong ¹ZHANG Jin-mei²

作者信息

1. Department of Otolaryngology Head and Neck, Tianjin First Central Hospital, Tianjin Institute of Otolaryngology, Tianjin Medical University, Tianjin 300192, China
2. Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China
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摘要

Abstract

Background Recurrence and local lymph node metastasis affected the prognosis of patients with laryngeal cancer.The aim of this study was to analyze clinical and pathological significance of vasculogenic mimicry (VM) in laryngeal squamous cell carcinoma (LSCC) and evaluate its contribution to prognosis.Methods Data of 168 cases of LSCC were reviewed retrospectively to reveal clinical pathology and prognostic significance of VM.CD31 and periodic acid-Schiff double staining was used to identify VM.Results VM in LSCC contributed to lymph node metastasis (P=0.003) and clinical progression.VM correlated to histopathology grade (P=0.001) of LSCC.VM was an adverse prognostic factor for both disease-specific survival (P=0.039) and metastasis-free survival (P=0.042) by univariate survival analyses.And it was an independent prognostic factor for only disease-specific survival (P=0.003) by multivariate survival analyses.Conclusions VM existed in LSCC.LSCC with VM has more potential to invasion and metastasis.

关键词

laryngeal squamous cell carcinoma/ vasculogenic mimicry/ prognosis/ metastasis

Key words

laryngeal squamous cell carcinoma/ vasculogenic mimicry/ prognosis/ metastasis

引用本文复制引用

LIN Peng,WANG Wei,SUN Bao-cun,CAI Wen-juan,LI Li,LU Hong-hua,HAN Chun-rong,ZHANG Jin-mei..Vasculogenic mimicry is a key prognostic factor for laryngeal squamous cell carcinoma: a new pattern of blood supply[J].中华医学杂志（英文版）,2012,125(19):3445-3449,5.

基金项目

This study was supported by grants from the National Natural Science Foundation of China (No.81102055),Tianjin Natural Science Foundation (No.11JCYBJC10700) and Technology Programme of Tianjin Health Bureau (No.2010KZ30). （No.81102055）

中华医学杂志（英文版）

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ISSN：0366-6999

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