肿瘤防治研究2012，Vol.39Issue(8)：910-913,4.DOI:10.3971/j.issn.1000-8578.2012.08.007
新辅助同步放化疗联合全系膜切除对局部进展期中低位直肠癌的治疗价值
Role of Combined Neoadjuvant Radiochemotherapy with TME in Treatment of Locally Advanced Mid-Distal Rectal Cancer
摘要
Abstract
Objective To explore the value and feasibility of combined neoadjuvant radiochemotherapy with TME in the treatment of locally advanced mid-distal rectal cancer. Methods One hundred and eleven patients with locally advanced mid-distal rectal cancer (T3~4N0~2M0) underwent preoperative radiochemotherapy with a dose of 50 Gy. Chemotherapy regimens were oxaliplatin combined capecitabine (combination group) and the single agent alone without oxaliplatin (single drug group). One hundred and five patients received radical(R0) TME operations within 2~10 weeks after radiochemotherapy and the efficacy of the radiochemotherapy could be evaluated according to the postoperative pathological results. Results Radical TME were carried out on 105 patients with clear margin. Sphincter-sparing surgery was performed in 42 (37. 8%) patients. Radical (RO) TME operations were performed in 15 (83. 3%) out of the 18 T4 patient,staged by the MRI and CT,after radiochemotherapy. There were no severe complications during the treatment of neoadjuvant radiochemotherapy or operation. There were 15 cases (14. 3%) with complete tumor regression,26 cases (24. 8%) with maximal tumor regression, 40 cases (38. 1%) with moderate tumor regression and 24 cases (22. 8%) with minimal tumor regression. Conclusion It is concluded that the combined neoadjuvant radiochemotherapy with TME leads to increased sphincter-sparing and radical(RO) surgery with no addition of complications, which is a feasible treatment on locally advanced mid-distal rectal cancer. It should be a preferred regimen for the locally advanced mid-distal rectal cancer.关键词
直肠肿瘤/新辅助治疗/放射疗法/化疗/全系膜切除Key words
Rectal neoplasms/ Neoadjuvant therapy/ Radiotherapy! Chemotherapy/ Total mesorectal excision分类
医药卫生引用本文复制引用
王仲照,周志祥,毕建军,张海增,周海涛,梁建伟,王征..新辅助同步放化疗联合全系膜切除对局部进展期中低位直肠癌的治疗价值[J].肿瘤防治研究,2012,39(8):910-913,4.基金项目
国家自然科学基金资助项目(30950013) （30950013）
