肿瘤防治研究2012，Vol.39Issue(8)：970-972,3.DOI:10.3971/j.issn.1000-8578.2012.08.022
乳腺癌患者术后服用三苯氧胺后子宫内膜病变的临床病理分析
Clinical and Pathologic Analysis of Endometrial Lesion in Postoperative Breast Cancer Patients Taking Tamoxifen
袁芳 1王福玲 1马德花 1初怡静 1崔竹梅1
作者信息
- 1. 266000山东青岛,青岛大学医学院附属医院东区妇科
- 折叠
摘要
Abstract
Objective To evaluate the effect of tamoxifen (TAM) on endometrium in postoperative breast cancer patients treated with TAM. Methods Hysteroscopy and endometrial biopsies were performed in 69 patients having abnormal vaginal bleeding or abnormal thickness of endometrial by ultrasound in TAM group and in 60 patients with postmenopausal bleeding without tamoxifen as control group. TAM group was divided into premenopausal and menopausal group or three groups including T≤1 year,l year<T< 2 years and T≥2 years according to the time with tamoxifen. Results The frequency of endometrial polyps and hyperplasia was higher in TAM group,especially in menopausal group. All the atypical hyperpla-sia and endometrioid carcinoma cases occurred in menopausal group. The occurrence of endometrial disease increased along with the duration of taking TAM. Conclusion Risk of endometrial disease in postoperative breast cancer patients treated with TAM will be increased,especially in menopausal patients taking TAM more than 2 years.关键词
三苯氧胺/子宫内膜/乳腺癌Key words
Tamoxifen/ Endometrium/ Breast cancer分类
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袁芳,王福玲,马德花,初怡静,崔竹梅..乳腺癌患者术后服用三苯氧胺后子宫内膜病变的临床病理分析[J].肿瘤防治研究,2012,39(8):970-972,3.
