癌变·畸变·突变2012，Vol.24Issue(5)：386-388,3.DOI:10.3969/j.issn.1004-616x.2012.05.017
菊花浸膏对大鼠的致畸毒性试验
Study on teratogenicity of Chrysanthemum indicum extract in SD rats
王凤岩 1陈瑞仪 1周轶琳 1张紫虹 1谭剑斌 1杨美玲 1胡帅尔 1李欣1
作者信息
- 1. 广东省疾病预防控制中心卫生毒理所,广东广州510300
- 折叠
摘要
Abstract
OBJECTIVE: To study the embryo toxicity and teratogenecity of Chrysanthemum indicum extract in SD rats. METHODS: SD rats successfully impregnated were divided into 4 groups (15-16 animals per group), included three Chrysanthemum indicum extract dosage groups (0.68, 2.03 , 6.09 g/kg) and one negative control group. During gestation from 7-16 days, animals were orally gavaged with Chrysanthemum indicum ectract once daily, clinical manifestations and weight of the pregnant rats were collected during the study. On the 20th day pregnant rats were euthanized and the weight of placenta, body weight and length of fetus and the appearance, visceral and skeletal malformations of fetus were examined. RESULTS: No statistically significant difference was found in all the assessed indices(including the weight gain of pregnant rats, average live fetus, absorptive fetus ratio, body weight and length of fetus) between dosage and control groups (P > 0.05). CONCLUSION: Under our experimental conditions, chrysanthemum indicum extract showed no significant effects in the toxicity of SD pregnant rats, had no apparent teratogenicity and embry otoxicity.
关键词
菊花浸膏/胚胎毒性/致畸作用/SD大鼠Key words
Chrysanthemum indicum extract/ embryotoxicity/ teratogenicity/ SD rats分类
医药卫生引用本文复制引用
王凤岩,陈瑞仪,周轶琳,张紫虹,谭剑斌,杨美玲,胡帅尔,李欣..菊花浸膏对大鼠的致畸毒性试验[J].癌变·畸变·突变,2012,24(5):386-388,3.
