安徽农业科学2012，Vol.40Issue(28)：13717-13719,3.
4,4'-二硝基-2,2'-联咪唑及其铜配合物的合成·表征及与DNA相互作用研究
Synthesis,Characterization and Interaction with ct-DNA of Copper( Ⅱ )Complex with 4,4'-dinitro-2,2'-biimidazole
杨莉宁 1姚琳 1余丽丽 1杨黎燕 1尤静1
作者信息
摘要
Abstract
[ Objective ] To supply theoretical foundation for directional synthesis of drugs, the interation of 4-nitroimidazole derivative and its complex with calf thymus DNA. [Method] 4,4'-dinitro-2,2'-biimidazole and its Copper(Ⅱ) complex have been synthesized and characterized. The interation of the compounds with DNA has been investigated by UV, fluorescence spectra and viscosity measurements. [Result] The data of elemental a-nalysis, UV, IR and molar conductivity indicated that the copper(Ⅱ) metal ions have coordinated with 4,4'-dinitro-2,2'-biimidazole. As a result of interaction between compounds and ct-DNA, the UV and fluorescence spectra of them have some certain change, and compounds also have different effects to the viscosity of DNA. [Conclusion] The possible composition of complex is Cu[ (NO2)2biim]2SO4 ? 2H2O and the interation of ligand and complex with calf thymus DNA are non-classical and partial intercalate modes respectively.关键词
4,4’-二硝基-2,2’-联咪唑/铜配合物/小牛胸腺DNAKey words
4,4'-dinitro-2,2'-biimidazole/ Copper(Ⅱ) complex/ ct-DNA分类
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杨莉宁,姚琳,余丽丽,杨黎燕,尤静..4,4'-二硝基-2,2'-联咪唑及其铜配合物的合成·表征及与DNA相互作用研究[J].安徽农业科学,2012,40(28):13717-13719,3.
