安徽农业科学Issue(30)：14668-14672,5.
细胞周期蛋白家族的生物信息学分析
Bioinformatics Analysis of Cyclin Families
摘要
Abstract
[Objective] Bioinformatics was carried out on sequence of cyclin families. [Method] The cyclins often species which had accomplished genome sequencing, were classified according to the sequence integrity and number of domain. The phylogenetic trees with completed monocycle and dicycle domain were constructed respectively. [Result] The cyclin sequences from 10 model species were analyzed and the results suggested that numbers and types of cyclins in these species significantly increased during evolution. Phylogenetic analysis of the cyclins with single-complete cyclin box domain and doube-complete cyclin box domains indicated that prokaryotic cyclins were made up of cyclins of prokaryote, PH080 and PCL in unicellular eukaryotes, P and U in plants and Y in animals, and from which eukaryotic cyclins were gradually evolved. The evolutionary trends of eukaryotic cyclins was increasing their numbers and types, and the evolutionary difference between animals and plants showed that animals mainly increased types of cyclins, whereas plants increased members of each cyclin type. Another evolutionary trends of eukaryotic cyclins was duplicating cyclin box domain, and the higher evolutionary of the species, the more types of cyclins with double cyclin box domain they had. [Conclusion] The study will provide reference for molecular evolution research of cyclin.关键词
细胞周期蛋白/结构域/进化分析Key words
Cyclin/ Domain/ Phylogenetic analysis分类
农业科技引用本文复制引用
万晶,冯沛春,王万军..细胞周期蛋白家族的生物信息学分析[J].安徽农业科学,2012,(30):14668-14672,5.基金项目
国家自然科学基金项目(2008～2010,30772742)资助. （2008～2010,30772742）
