北京中医药大学学报2012，Vol.35Issue(10)：688-691,4.
比较用红芪和用黄芪的经典补益方对免疫抑制小鼠免疫功能的影响
Influences of classic tonifying and replenishing formulas containing Hongqi (Radix Hedyseri) and Huangqi (Radix Astragali) on immune function in immunosuppressive mice
摘要
Abstract
Objective To compare and study the regulative effect of Hongqi (Radix Hedyseri,) replacing Huangqi (Radix Astragali) in classic tonifying and replenishing formulas on immune function in immunosuppressive mice. Methods The mouse model of immunosuppression was established by intraperitoneal injection of cyclophosphamide ( CTX ) . The same dose of Huangqi was replaced by Hongqi in the formula of invigorating spleen and replenishing qi ( Buzhongyiqi formula) and formula of replenishing qi and tonifying blood ( Yiqiyangxue formula) , and then the formulas were given to mice intragastrically. The thymus index, spleen index, lymphocyte subgroup and content of interleukin-4 (IL-4) and interferon-γ (IFN-γ) were detected. Results The formulas containing Huangqi or Hongqi all raised thymus index and spleen index in immunosuppressive mice ( P < 0. 01 ) , increased the percentage of lymphocytes CD 19 + , CD3+ , CD4 +0 and CD8 + ( P <0.01 ) , and increased the content of serum IL-4 and IFN-γ ( P < 0. 01 ). In the groups with Buzhongyiqi formula and Yiqiyangxue formula containing Hongqi, spleen index, lymphocyte CD3 + and content of IFN-γ were slightly higher than those in the groups with the formulas containing Huangqi (P < 0. 01). The comparison in other indexes between the formulas containing Hongqi and those containing Huangqi showed that the difference was not statistically significant ( P > 0. 05 ). Conclusion The Buzhongyiqi formula and Yiqiyangxue formula containing Hongqi and those containing Huangqi all can improve the immunosuppressive effect of CTX, and Hongqi has higher immunoregulation effect than Huangqi.关键词
红芪/黄芪/补中益气方剂/益气养血方剂/免疫抑制/淋巴细胞/小鼠Key words
Hongqi (Radix Hedyseri) / Huangqi (Radix Astragali) / formulas of invigorating spleen and replenishing qi/ formulas of replenishing qi and tonifying blood/ immunosuppression/ lymphocyte/ mice分类
医药卫生引用本文复制引用
张武德,张李峰,程卫东,桂曼曼,李雪嫣..比较用红芪和用黄芪的经典补益方对免疫抑制小鼠免疫功能的影响[J].北京中医药大学学报,2012,35(10):688-691,4.基金项目
中国博士后科学基金资助项目(No.20090450017),教育部高等学校博士点基金资助项目(No.200807330006) （No.20090450017）
