北京中医药大学学报2012，Vol.35Issue(10)：696-698,3.
柴胡注射液对LPS发热模型大鼠解热药效的研究
Antipyretic effect of Chaihu Injection in rat model with LPS-induced fever
高阳 1王志斌 2左泽平 1胡宇驰 2曹春然 2郭玉东 2王碧松2
作者信息
- 1. 北京中医药大学中药学院 北京100102
- 2. 北京市药品检验所
- 折叠
摘要
Abstract
Objective To study the antipyretic effect of Chaihu Injection in rat model with experimental fever induced by lipopolysaccharide ( LPS). Methods The rat model of fever was established by intraperitoneal injection of LPS (100μg/kg). The influence of Chaihu Injection (5 mL/kg, 2.5 mL/kg and 1. 25 mL/kg) on body temperature of model rats in all groups was observed, and recorded after injecting for 0.5 h, 1 h, 1.5 h, 2h, 2.5 h, 3 h, 3.5 h, 4 h, 4.5 h, 5 h, 5.5 h, 6h,6.5 h, 7 hand 8 h. The average heating curve was drawn. Results After intraperitoneal injection of LPS ( 100 μg/ kg) , the rats showed obvious three-phase fever and the heating peak value (1.69 t ) appeared 4 hours after modeling. The intramuscular injection of Chaihu Injection (5 mL/kg, 2. 5 mL/kg and 1. 25 mL/ kg) decreased significantly the body temperature of rats and continued for 7 hours to 8 hours. The average heating values at different time points showed that the antipyretic effect of Chaihu Injection had a better dose dependence. Conclusion Chaihu Injection has a nice antipyretic effect in rat model with LPS-induced fever, and shows a better dose dependence.关键词
柴胡注射液/脂多糖/发热模型/解热作用/大鼠Key words
Chaihu Injection/ lipopolysaccharide/ model with fever/ antipyretic effect/ rats分类
医药卫生引用本文复制引用
高阳,王志斌,左泽平,胡宇驰,曹春然,郭玉东,王碧松..柴胡注射液对LPS发热模型大鼠解热药效的研究[J].北京中医药大学学报,2012,35(10):696-698,3.
