北京中医药大学学报2012，Vol.35Issue(10)：712-715,720,5.
肺复方治疗中晚期老年非小细胞肺癌多中心临床研究
Fei Fufang for senile non-small cell lung cancer: a multi-center randomized controlled clinical study
摘要
Abstract
Objective To review initially the curative effect of Fei Fufang on senile non-small cell lung cancer. Methods The cases (n = 120) were selected by applying multi-center randomized controlled method, and then divided into treatment group (treated with Fei Fufang) and control group (treated with chemotherapy and Chinese medicinals, each n =60). The clinical symptoms, quality of life, changes of body weight and tumor size, time of tumor progression (TTP) , median survival time ( MST) , survival rate and toxic and adverse reactions were observed, followed up and recorded in two groups. Results The total effective rate (tumor size) was 5. 00% in control group and 21. 67% in treatment group (P<0.05). The stable rate was 75.00% in treatment group, which was higher than 66.6% in control group ( P > 0. 05 ). TTP was 5.0 months in treatment group and 4. 8 months in control group ( P >0. 05 ) . MST was 13. 2 months in treatment group and 10. 6 months in control group ( P > 0. 05 ) . One-year survival rate was 48.33% and two-year survival rate was 31. 67%, which were higher respectively than 36. 67% and 15. 00% in control group ( P < 0. 05 in two-year survival rate). The treatment group had better effects on clinical symptoms, quality of life and body weight than control group (P <0. 05) and had no significant toxic and adverse reactions. Conclusion Fei Fufang for treating senile non-small cell lung cancer, especially for the patients with mid-stage or late-stage lung cancer, can relieve clinical symptoms, improve quality of life and body weight, stabilize tumor size, delay the development of disease, and prolong survival time.关键词
老年肺癌/肺复方/中药治疗/临床研究Key words
senile lung cancer/ Fei Fufang/ treatment with Chinese medicine/ clinical study分类
医药卫生引用本文复制引用
蒋益兰,潘敏求,蔡美,李琳霈,周坚,刘伟..肺复方治疗中晚期老年非小细胞肺癌多中心临床研究[J].北京中医药大学学报,2012,35(10):712-715,720,5.基金项目
湖南省科技厅科技计划资助项目(No.2008SK3093) （No.2008SK3093）
