重庆医学2012，Vol.41Issue(28)：2951-2953,后插1,4.DOI:10.3969/j.issn.1671-8348.2012.28.020
VEGF在大鼠重症急性胰腺炎中的表达及意义
The significance of VEGF expression in the severe acute pancreatitis
摘要
Abstract
Objective To investigate the expression of VKGF in severe acute pancreatitis (SAP) , we preliminarily discuss the effect of VEGF in SAP. Methods Thirty-six female SD rats were randomly divided into sham-operated group(Sham group;n = 18) and severe acute pancreatitis model group(SAP group;n = 18). SAP was induced by retrograde injection of 5% sodium taurocholate in the pancreaticobiliary duct. The serum,ascites and pancreatic tissue of each group were detected at 3h,6h,12h after the operation. The severity of pancreatitis was assessed according to histological scoring. The expression of VKGF in the pancreatic tissues was observed by Western Blot,immunohistochemistry method. Results At each of the time points for measurement,both the serum Amylase and the scores of pancreatic tissue injury were significantly higher in SAP group than them of sham group(P<0. 01). Compared with the sham group, the expressions of VKGF in the pancreatic tissues of SAP group were significantly up-regulated following the operation(P<0. 01). Conclusion The expression of VKGF may play an important role in the pathological change and involve in hemorrhage and necrosis in SAP.关键词
重症急性胰腺炎/血管内皮生长因子/大鼠Key words
severe acute pancreatitis/ VKGF/rats引用本文复制引用
李鑫,刘静,王东..VEGF在大鼠重症急性胰腺炎中的表达及意义[J].重庆医学,2012,41(28):2951-2953,后插1,4.基金项目
四川省卫生厅科研基金资助项目(090247). （090247）
