重庆医学2012，Vol.41Issue(28)：2954-2955,2958,后插2,4.DOI:10.3969/j.issn.1671-8348.2012.28.021
EsA对BXSB狼疮性肾炎小鼠作用观察
Effect of Esculentoside A on therapeutic and cytokines secretion of lupus nephritis in BXSB mice*
摘要
Abstract
Objective To investigate the effect of Ksculentoside A(KsA) on therapeutic and cytokines secretion in BXSB mice and the possible mechanism of KsA in treating lupus nephritis(LN). Methods 24 male BXSB mice at the age of 12 weeks were randomly divided into 3 groups:untreated model group,EsA(5 mg · kg 1 · d 1)-treated model group and EsA(20mg · kg 1 · d 1)-treated model group. All mice at the age of 16 weeks were killed to obtain samples. Results KsA administration markedly alleviated urine protein/urine creatinine, improved pathological kidney damage and reduced the serum IL-6 and TNF-α level. Conclusion EsA may play significant roles in the treatment of BXSB mice through modulation on inflammatory cytokines.关键词
商陆皂苷甲/狼疮肾炎/白细胞介素6/肿瘤坏死因子α/BXSB小鼠Key words
EsA/lupus nephritis/interleukin-6 /tumor necrosis facter-α/BXSB mice引用本文复制引用
马华林,张祥贵,张欣洲,徐莹..EsA对BXSB狼疮性肾炎小鼠作用观察[J].重庆医学,2012,41(28):2954-2955,2958,后插2,4.基金项目
遵义医学院珠海校区校区科研启动基金资助项目(KY200607). （KY200607）
