重庆医学2012，Vol.41Issue(30)：3149-3151,3.DOI:10.3969/j.issn.1671-8348.2012.30.008
原发性干燥综合征合并非霍奇金淋巴瘤16例临床特征分析
The clinical analysis of 16 patients with primary sj(o)gren's syndrome combined with nonhodgkin lymphoma
摘要
Abstract
Objective To explore the clinical feature of primary sjogren s syndrome(pSS) combined with nonhodgkin lymphoma (NHL) and provide evidence for its privation. Methods The clinical features, lab detection, pathological characters of 16 patients with pSS combined with NHL(study group) were analyzed and compared to 20 patients with pSS but not NHL(control group). Results The 16 patients in study group were diagnosed during 2 months to 8 years after diagnosed of pSS. Compared to control group,the specific clinical features of study group were lymphadenectasis,swelling of parotid gland and fever, which were obviously more than in control group(P<0. 05). There were 7 patients(43. 8%) in study group whose leucocyte was lower than that was significant higher than in control group(15. 0%),(x2=12. 086 , P<0. 05). The ratio of red blood cells lower than in study group(37. 5%) was higher than that in control group(15. 0%),(x2 = 8. 386, P<0. 05). The others including ANA, anti-SSA/SSB, RF, PC-NA,immunoglobulin,and complement were not different in the two groups(P>0. 05). It was found that the expression of p53,bd-6,and PCNA was up-regulated in study group than control group detected by immunohistochemistry(P<0. 01). Conclusion The specific clinical features of pSS combined with NHL were lymphadenectasis,swelling of parotid gland,fever,lower leucocyte or red blood cells. Moreover, the up-regulated expression of p53、Bcl-6 and PCNA is helpful to direct the diagnosis and prognosis for the patients with pSS combined with NHL.关键词
干燥综合征/淋巴瘤,非霍奇金/实验室技术和方法Key words
sjogresn s syndrome/lymphoma,non-hodgkin/laboratory techniques and procedures引用本文复制引用
杨敏,莫汉有,李宝贞,石宇红,许佳,周润华..原发性干燥综合征合并非霍奇金淋巴瘤16例临床特征分析[J].重庆医学,2012,41(30):3149-3151,3.基金项目
广西壮族自治区卫生厅课题基金资助项目(Z2010303,Z2008260). （Z2010303,Z2008260）
