重庆医学2012，Vol.41Issue(31)：3252-3254,3.DOI:10.3969/j.issn.1671-8348.2012.31.005
递增负荷运动对大鼠抑郁症模型行为学功能及孤啡肽水平的影响
Effects of progressive load exercise on ethology and orphanin levels in depression rat model
冯英凯 1杨庆华2
作者信息
- 1. 解放军第一医院呼吸内科,兰州,730030
- 2. 重庆市卫生信息中心,400014
- 折叠
摘要
Abstract
Objective To explore the therapeutic value and possible mechanism of motion on treating depression. Methods Depression rat model was introduced by applying chronic stress with medium intensity. The experimental animals were randomly divided into normal group,model group, fluoxetine group and motion group. Open-Field method was used to examine ethologic parameters in different groups ;ELISA was applied to measuring orphanin levels in plasma and hypothalamus. Results After two weeks treatment of medication or motion, etho logic function was improved in the experimental animals. As compared with those in model group,the orphanin levels in plasma and hypothalamus were significantly lower,and the differences were statistically significant(all P<0. 05). There was no significant difference in orphanin level in plasma and hypothalamus between fluoxetine group and motion group. Conclusion The therapeutic effect is similar between fluoxetine group and motion group. Motion therapy has pronounced effect on depression,and can be used as a choice for treatment.
关键词
抑郁症/运动疗法/行为学/孤啡肽Key words
depressive disorder/execise therapy/ ethology/orphanin引用本文复制引用
冯英凯,杨庆华..递增负荷运动对大鼠抑郁症模型行为学功能及孤啡肽水平的影响[J].重庆医学,2012,41(31):3252-3254,3.
