重庆医学2012，Vol.41Issue(33)：3512-3514,封3,封4,5.DOI:10.3969/j.issn.1671-8348.2012.33.020
锝气体肺通气显像在家兔急性肺栓塞模型制备中的作用
The role of Technegas pulmonary ventilation imaging in establishing rabbit models of acute pulmonary embolism
摘要
Abstract
Objective To explore the feasibility of creating rabbit acute pulmonary embolism model by jugular vena catheter u sing polyester sponge for emboli. To study the methods of Technegas pulmonary ventilation imaging and preliminary evaluate the image quality. Methods Twenty experimental rabbits were randomly divided into 2 groups,that is,the experimental group(n = 20) , and the control group(n = 2). The rabbits of experimental group were further equally randomized into 4 subgroups,2 hour group, 24 hour group,3 day group and 7 day group. The animal model was prepared by jugular vena catheter using polyester sponges as emboli. Pulmonary ventilation imaging was performed after the operation, then the rabbits were killed at the corresponding time points and the pulmonary tissue were pathological inspected to search and record the numbers and location of emboli. The control group rabbits were injected physiological saline solution via catheter after operation,and killed at 1 day and 3 days respectively. Results One rabbitdied during the operation,and the left 19 of 20 rabbits were made as acute pulmonary embolism model successful ly. Totally 285 pulmonary arteries were anatomized after Technegas imaging. 74 emboli were found and 61 pulmonary embolisms were made. All of the 19 rabbits were undergoing pulmonary ventilation imaging with different time and got clear images respective ly. Conclusion The method of creating rabbits acute pulmonary embolism by jugular vena catheter using polyester sponges as em boll is simple and with high successful rate. The method for Technegas pulmonary ventilation imaging used in the research is simple and the image quality is satisfactory.关键词
肺栓塞/动物模型/肺通气显像Key words
pulmonary embolism/ animal model/ pulmonary ventilation imaging引用本文复制引用
蒋仁容,汤小惠..锝气体肺通气显像在家兔急性肺栓塞模型制备中的作用[J].重庆医学,2012,41(33):3512-3514,封3,封4,5.基金项目
重庆市自然科学基金资助项目(CSCT2009BB4146). （CSCT2009BB4146）
