中德临床肿瘤学杂志（英文版）2012，Vol.11Issue(12)：683-688,6.DOI:10.1007/s10330-012-1088-4
DNA修复基因BRCA1和DNA-PKcs在放射治疗中有很大的潜能
DNA repair genes BRCA1 and DNA-PKcs have great potential in radiation therapy
Jiao Yang 1Ximing Xu 2Yanrong Hao1
作者信息
- 1. Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China
- 2. Department of Radiotherapy, Clinical Cancer Center, the People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021, China
- 折叠
摘要
Abstract
Radiotherapy is a part of the front-line treatment regime for many cancers. The mechanisms of radiation-induced effects in cancers mainly involves double-strand breaks (DBS) which plays very important role in maintaining the stability of gene. As DNA repair gene breast cancer 1 (BRCA1) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) can act to maintain genetic stability though two distinct and complementary mechanisms for DNA DSB repair-homologous recombination (HR) and non-homologous end joining (NHEJ). Therefor, BRCA1 and DNA-PKcs are closely associated with radiation sensitivity, which means that they may be used as a useful tool to predict radio sensitivity in human tumour cells.关键词
breast cancer 1 (BRCA1)/ DNA-dependent protein kinase catalytic subunit (DNA-PKcs)/ double-strand breaks (DBS) repair/ radiation sensitivityKey words
breast cancer 1 (BRCA1)/ DNA-dependent protein kinase catalytic subunit (DNA-PKcs)/ double-strand breaks (DBS) repair/ radiation sensitivity引用本文复制引用
Jiao Yang,Ximing Xu,Yanrong Hao..DNA修复基因BRCA1和DNA-PKcs在放射治疗中有很大的潜能[J].中德临床肿瘤学杂志（英文版）,2012,11(12):683-688,6.
