摘要
Abstract
Objective; To investigate the effect of naloxone for the treatment of infantile apnea. Methods; With admission order, 40 cases of infantile secondary apnea admitted into our hospital from December 2006 to December 2011, were divided into a treatment group (odd-day admission) and a control group (even-day admission) equally. When the appearance of apnea was happened in the first time, the treatment group was given 0.4 mg naloxone injection intravenously, q 6 h. After apnea was controlled, naloxone was reduced gradually and withdrawn after five days without episodes of apnea. When the appearance of apnea was happened in the first time, the control group was immediately given 5 mg/kg aminophylline with 5% glucose 30 mL iv in 30 minutes. After 12 hours, the dose of aminophylline was reduced to 2. 5 mg/kg with 5% glucose 30 ml. iv. The infusion speed was 1 mg/(kg ?h), 12 hours at a time. Aminophylline was withdrawn after five days without episodes of apnea or adverse reactions happened. Routine treatment was applied to the two groups, such as maintaining the correct posture, foot tapping, back-supporting breathe and arousal stimulation. If there were no effects of routine physical therapy, positive-pressure oxygen was given to the infants with cyanosis. Results; In the treatment group, effect was obvious in 10 cases, good in 8 cases and not efficient in 2 cases. In the control group, effect was obvious in 8 cases, good in 7 cases and not efficient in 5 cases. There was a significant difference of apparent efficiency between the two groups (P<0.05) and the difference of total effective rate was also significant (P<0.01). Conclusions: Naloxone is fast-acting, safe and efficient in the treatment of infantile apnea. It may be recommended as the chief drug for the treatment of infantile apnea.关键词
纳洛酮/婴儿/呼吸暂停Key words
Naloxone/ Infant/ Apnea分类
医药卫生
