法医学杂志2012，Vol.28Issue(5)：366-370,5.DOI:10.3969/j.issn.1004-5619.2012.05.011
表观遗传学在法医学中的应用研究进展
Progress on Epigenetics Applications in Forensic Science
摘要
Abstract
Epigenetics is the study of heritable changes in gene expression other than changes in the underlying DNA sequence. Such changes include DNA methylation, histone modification, chromatin remodeling, genomic imprinting, X chromosome inactivation and non-coding RNA regulation. Recent progresses on epigenetics open new possibilities in tackling these challenging problems in forensic science, including identification of fetal paternity testing in embryonic period, determination of the necessary allele in paternity testing, discrimination of identical twins, origination analysis of micro tissue, verification of forged DNA. This review focuses on epigenetics concept and its latest application in the field of paternity testing, age estimation, discrimination between the twins, identification of tissue of origin, and estimation of postmortem interval.关键词
法医遗传学/表观遗传学/综述[文献类型]Key words
forensic genetics/ epigenetics/ review[publication type]分类
社会科学引用本文复制引用
杨雅冉,王鹏翔,方向东,严江伟..表观遗传学在法医学中的应用研究进展[J].法医学杂志,2012,28(5):366-370,5.基金项目
国家自然科学基金资助项目(81172909,81072511) （81172909,81072511）
上海市法医学重点建设实验室开放课题(KF1001) （KF1001）
